BACKGROUND The role of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) in the regulation of energy metabolism and immune system by locally reactivating glucocorticoids has been extensively studied. Experiments determining initial rates of enzyme activity revealed that 11beta-HSD1 can catalyze both the reductase and the dehydrogenase reaction in cell lysates, whereas it predominantly ca...

Individuals exposed to carcinogenic aromatic amines excrete arylamine Nand O-glucuronide metabolites. This study assessed the susceptibility of selected glucuronides to hydrolysis by human and Escherichia coli b-glucuronidase. Nor O-glucuronides were prepared with the following aglycones: benzidine, N-acetylbenzidine, N*-hydroxy-N-acetylbenzidine, N-hydroxy-N-acetylbenzidine, N-hydroxy-N,N*-dia...

In an in vitro study, we compared the cytochrome P450 (CYP)-dependent metabolism and drug interactions of the acid and lactone forms of the 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitor atorvastatin. Metabolism of atorvastatin acid and lactone by human liver microsomes resulted in para-hydroxy and ortho-hydroxy metabolites. Both substrates were metabolized mainly by CYP3A4 and CYP3A5...

Six new chromones, 6-methoxy-2-[2-(3-methoxy-4-hydroxyphenyl)ethyllchromone (2), 6,8-dihydroxy-2-(2-phenylethyl)chromone (3), 6-hydroxy-2-[2-(4-hydroxyphenyl)ethyl]chromone (4), 6-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (5), 7-hydroxy-2-(2-phenylethyl)chromone (6), and 6-hydroxy-7-methoxy-2-(2-phenylethyl)chromone (7) were isolated from the ether extract of agarwood in addition to a known ...

An efficient approach for the synthesis of 3-substituted-3-hydroxy-2-oxindoles has been achieved via an aldol reaction of α,β-unsaturated ketones and isatins using arginine as an organocatalyst. A range of 3-substituted-3-hydroxy-2-oxindoles were obtained in moderate to high (up to 99%) yields. These 3-substituted-3-hydroxy-2-oxindoles with an additional enone moiety provide an opportunity for ...

3-Hydroxy-a-calacorene was identified in extracts from cold-shocked seedlings of cotton (Gossypium hirsutum L.) and kenaf (Hibiscus cannabinus L.), both of which are members of the Malvaceae family. ( )-3-Hydroxy-a-calacorene was isolated from Heterotheca inuloides Cass. (Asteraceae). HPLC on a chiral stationary phase column showed that the 3-hydroxy-acalacorene from cotton and kenaf had the sa...

To assess serum 25-hydroxy vitamin D [25(OH) D] level in Egyptian children with JIA and correlate its subtypes of disease activity scoring.

3-Hydroxy fatty acids are important chiral building blocks of lipopeptides and metabolic intermediates acid oxidation, respectively. The analysis the stereochemistry such biomolecules has significant practical impact to elucidate assign enzymatic specificity biosynthesis machinery. In this work, a new mass spectrometry compatible direct ultra high performance liquid chromatography separation me...

Thesis AbstractBackground: Heterocyclic are known to have multiple applications in particular biomedical settings. Aim: The present study reports a convenient protocol for the design and synthesis of new heterocyclic compounds incorporating 1- hydroxy-naphthyl angular chromones bearing allylnaphthyl fragments. Materials Methods: versatile precursor 2-acetyl-4- allyl-1-hydroxy naphthalene was su...