Vanadium plays an important role in life and one of its most relevant properties identified is its capacity to act as insulin-enhancing agent, either in the form of its inorganic salts or complexes with organic ligands. Besides the antidiabetic action, vanadium complexes are known to possess potent anticancer activity, which deserve increasing attention for application to biomedical sciences. S...

X-band EPR features in the region of 90-150 mT have previously been attributed to heme ci of the b6 complex [Zhang H, Primak A, Bowman MK, Kramer DM, Cramer WA (2004) Biochemistry 43:16329-16336] and interpreted as arising from a high-spin species. However, the complexity of the observed spectrum is rather untypical for high-spin hemes. In this work, we show that addition of the inhibitor 2-n-n...

The synthesis and characterization of different ether and ester derivatives of 8-hydroxyquinoline have been made. UV-visible and fluorescence spectra of these compounds have revealed spectral dependence on both solvent and O-substituent. The fluorescence intensity of ether derivatives revealed higher intensity for 8-octyloxyquinoline compared with 8-methoxyquinoline, whereas those of ester deri...

BACKGROUND Allelopathic functions of plant-released chemicals are often studied through growth bioassays assuming that these chemicals will directly impact plant growth. This overlooks the role of soil factors in mediating allelopathic activities of chemicals, particularly non-volatiles. Here we examined the allelopathic potential of 8-hydroxyquinoline (HQ), a chemical reported to be exuded fro...

Pseudomonas methanica KY4634 was found to produce 5-lipoxygenase inhibitor designated KF8940, MY12-62a and MY12-62c. The inhibitors were purified by solvent extraction, silica gel column chromatography, reversed-phase low pressure liquid chromatography and crystallization. The chemical structures of KF8940, MY12-62a and MY12-62c were determined to be 2-n-heptyl-4-hydroxyquinoline-N-oxide, 2-n-h...

We studied the adsorption of tris(8-hydroxyquinoline)aluminum (Alq3) molecules on cobalt surfaces using density functional theory with the generalized gradient approximation. The van der Waals interaction between Alq3 molecules and cobalt surfaces was included by the dispersion correction. Magnetization of Alq3 molecules, adsorption energies, and bonding energies were obtained for smooth and de...

Iron is an essential cellular nutrient, being a critical cofactor of several proteins involved in cell growth and replication. Compared with normal cells, neoplastic cells have been shown to require a greater amount of iron, thus laying the basis for the promising anticancer activity of iron chelators. In this work, we evaluated the effects of molecules with iron chelation activity on neuroblas...

Articles you may be interested in Phosphorescent-sensitized triplet-triplet annihilation in tris(8-hydroxyquinoline) aluminum Long-range energy transfer of singlet and triplet excitations in dye-doped tris(phenylquinoxaline) Infrared organic light emitting diodes using neodymium tris-(8-hydroxyquinoline) The photoluminescence of aluminum tris͑8-hydroxyquinoline͒ ͑AlQ͒ has been studied as a function...

Transferrin receptor (TR) performs the major function of binding and internalizing its specific iron-loaded ligand, transferrin, and its expression is closely linked to the proliferation status of the cell. This study was undertaken to elucidate TR expression in the hyperplastic lesion of hepatocyte in chemically induced hepatic carcinogenesis. The resistant hepatocyte model was chosen for a ra...

An extensive literature has developed in recent years in the field of chelate compounds with special reference to their antimicrobial properties. Thus, for example, the copper chelate of oxine (8-hydroxyquinoline) has been the subject of numerous investigations (Hollingshead, 1956). Thiosemicarbazones (TSC), which are compounds capable of forming chelates, have been investigated by Domagk (1950...