Osteosarcoma is the most frequent primary bone malignant tumor that develops mainly in children and adolescents. Despite recent improvements in chemotherapy and surgery, survival rate is approximately 50% after 5 years. Osteoprotegerin (OPG) is a potent inhibitor of osteoclast differentiation and activation, but its use as therapeutic agent in cancer-associated osteolysis remains controversial ...

Cytological cancer screening that targets genetic or epigenetic abnormalities may be a viable alternative to morphological screening. Detecting cancer cells by specific genetic markers helps their easy detection in cytological samples. We recently established the telomerase-specific replication-selective adenovirus OBP-401, in which the human telomerase reverse transcriptase (hTERT) gene promot...

This Issue Brief provides an initial analysis of the potential financial impact on private-sector retirement benefits of the retirement savings account cap included in the Obama administration's FY 2014 budget proposal. It finds that although a very small percentage of current 401(k) participants with IRA accounts have combined balances sufficient to be immediately affected by the proposed limi...

PURPOSE To determine whether protein tyrosine phosphatase 1B (PTP1B) is expressed in rat retinal pigment epithelium (RPE) cells, to evaluate whether inhibition of PTP1B contributes to initiation of RPE cells into an active state, and to investigate the signaling pathways involved in this process. METHODS Rat retinas were detached by trans-scleral injection of 1.4% sodium hyaluronate into the ...

This Issue Brief examines the 1999 contribution behavior of 1.7 million 401(k) plan participants drawn from the EBRI/ICI Participant-Directed Retirement Plan Data Collection Project. The findings in this paper build on previous academic research examining the contribution activity of 401(k) participants, by using a large sample of participants in a wide range of plan sizes and by examining in d...

Objective: To review the research literature published within the past 10 years regarding the impact of media on children and adolescents. Method: Media categories researched with computer technology included television and movies, rock music and music videos, advertising, video games, and computers and the Internet. Results: Research prior to 1990 documented that children learn behaviors and h...

This paper uses the 1998 Survey of Consumer Finances to identify the factors that determine whether an eligible employee elects to participate in a 401(k) plan and the magnitude of the employee’s contribution. The conclusion is that the most important factor affecting employees’ participation and contribution decisions is their planning horizon. Those with planning periods of less than two year...

Over the past decade or so, many private and publicly held companies have moved away from providing employees with company-funded pensions upon retirement to a retirement system that requires both employee and company contributions to fund an individual’s retirement. These so-called 401(k) retirement plans usually require the employee to choose among different investment vehicles, including mut...