Humoral hypercalcemia of malignancy is a common metabolic disturbance associated with solid tumors, but it also occurs in lymphoma patients. Among these, low grade B-cell lymphoma accounts for only few cases, in which secretion of parathyroid hormone-related protein (PTHrP) remains even exceptional. We report the very rare case of a patient with a CLL type low grade leukemic B-cell lymphoma sho...

Osteoporosis is a major public health problem despite widespread use of bisphosphonate therapy. PTH(1-34) is a more effective treatment; but its use has been limited by side effects (hypercalcemia, tumor risk) and inconvenient dosing (daily injection). Long-acting forms of PTH are also effective but cause severe hypercalcemia, presumably from effects in kidney. We hypothesized that targeted del...

Introduction One of the most interesting aspects of the hypercalcemia of malignancy is that it is unlikely that the hypercalcemia is due to the secretion by the tumor cells of one gene product which causes osteoclastic bone resorption and hypercalcemia, but rather that multiple tumor products work in concert on bone and kidney to overwhelm the normal compensatory mechanisms which guard calcium ...

Hypercalcemia is a rare complication of malignancy in children. We present two children, one of whom is the youngest reported, with CALLA+ B-cell acute lymphoblastic leukemia (ALL) who developed hypercalcemia at the time of diagnosis and were treated with relatively low-dose (0.5 mg/kg) intravenous pamidronate successive to conventional therapy. No major side effects were encountered except tra...

Background Hypercalcemia is a common complication of adult malignancies, but uncommon in childhood cancers. The mechanism leading to hypercalcemia varies with the primary tumour and can include the following: 1) Increased osteoclastic activity at the site of the tumour in the bone marrow 2) A paraneoplastic phenomenon secondary to PTH-related peptide (PTHrP) secretion or 1,25–dihydroxyvitamin D...

Hypercalcemia as a complication of carcinoid tumors is extremely rare. Accordingly, we report the case of a 55-year-old male with metastatic carcinoid tumor and hypercalcemia, which corrected when the patient was treated with octreotide for symptomatic relief of watery diarrhea. The etiology of the hypercalcemia is presumed to be a neoplastic expression of fibroblast growth factor-23, which was...

Digital Object Identifier: 10.1188/04.CJON.209-210 Hypercalcemia is a metabolic condition that occurs when the serum calcium level rises above the normal range of 9–11 mg/dl (Myers, 2001; Smith, 2000). It is a complex metabolic oncologic emergency that can be life threatening. This column is the first of a two-part series about hypercalcemia of malignancy (HCM). Part I focuses on the pathophysi...

12 Kawaguchi M, Mitsuhashi Y, Kondo S. Iatrogenic hypercalcemia due to vitamin D3 ointment (1,24 (OH)2D3) combined with thiazide diuretics in a case of psoriasis. J Dermatol, 2003: 30: 801–804. 13 Ohigashi S, Tatsuno I, Uchida D, et al. Topical treatment with 22-oxacalcitriol (OCT), a new vitamin D analogue, caused severe hypercalcemia with exacerbation of chronic renal failure in a psoriatic p...

Background: The effects of vitamin D in skeletal system, biological metabolism and immune system function are well shown. Cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) are two major types of vitamin D. Vitamin D deficiency is widely in human population and vitamin D intoxication is very rare. Case Description: The patient is 37-years old bodybuilder man who referred to emergency...

A 39-year-old woman was admitted to our hospital with symptoms of general fatigue, nausea, and vomiting that appeared three months after she stopped seven years of medroxyprogesterone acetate (MPA) medication for endometrial stromal sarcoma. Laboratory tests demonstrated moderate hypercalcemia. Several tests demonstrated that she was suffering from adrenal insufficiency. Glucocorticoid suppleme...