There is substantial evidence suggesting that angiotensin II plays an important role in elevating blood pressure of spontaneously hypertensive rats, despite normal plasma renin activity, and that converting enzyme inhibitors (captopril) can effectively normalize blood pressure in the spontaneously hypertensive rats. One mechanism by which angiotensin II induces hypertension is via oxidative str...

Hypertensive disorders of pregnancy, including pre-existing and gestational hypertension, preeclampsia eclampsia, complicate up to 10% pregnancies represent a significant cause maternal perinatal morbidity mortality. Despite some differences in guidelines, there is consensus that severe hypertension mild with organ dysfunction should be managed. However, achieving target values below 160/110 mm...

The hexane insoluble fraction of the Garcinia dulcis (GD) flower extract comprises mainly camboginol and morelloflavone which possess potent in vivo vitro antioxidant properties. This study aimed to evaluate effects 4-week oral administration GD on arterial blood pressure (ABP) excretory function kidney 2-kidneys-1-clip (2K1C) renovascular hypertensive rats (total=12) compared sham operated (SO...

The present study was designed to investigate whether non-insulin-dependent diabetic hypertensive patients exhibit abnormalities in intracellular sodium metabolism similar to those described for essential hypertensive patients. Both normotensive and hypertensive non-insulin-dependent diabetic patients had similar average values of both Na+-Li+ countertransport and Na+-K+ cotransport compared wi...

Cognitive functions were assessed in hypertensive and sex and age matched healthy controls using auditory event related evoked potential 'odd ball' paradigm. The N2 and P3 latencies in the hypertensive subjects were significantly delayed as compared to controls. There was also correlation of blood pressure (BP) with N2 latency in hypertensive group. These findings suggest that cortical neurophy...

In young rats consuming 1% NaCl drinking solution, unilateral nephrectomy and bilateral adrenal enucleation caused a hypertension. Plasma corticosterone concentration in hypertensive rats was not significantly higher than that of normotensive control rats in early hypertensive or chronic hypertensive stage. At the end of experiment, each rat received an intravenous injection of 0.4 microCi/g of...