The aim of the work was to determine antidiabetic effect a sitagliptin and aminoguanidine combination in rats with experimental diabetes mellitus. Materials methods. study carried out on male Wistar C57BL/KsJ-db/db mice. According models used, it divided into 4 series, which alloxan, steroid-induced (dexamethasone) streptozotocin-nicotinamide-induced mellitus (DM) were formed, respectively, rat...

INTRODUCTION Although numerous studies showed an improvement in glycemic control in type 1 diabetic patients treated with long-acting insulin analogue detemir compared with Neutral Protamine Hagedorn (NPH) insulin, the beneficial effects of insulin detemir has not been confirmed by all investigators. OBJECTIVES The aim of the study was to compare the effect of treatment with detemir insulin v...