BACKGROUND Mutations of the NR5A1 gene encoding steroidogenic factor-1 have been reported in association with a wide spectrum of 46,XY DSD (Disorder of Sex Development) phenotypes including severe forms of hypospadias. METHODOLOGY/PRINCIPAL FINDINGS We evaluated the frequency of NR5A1 gene mutations in a large series of patients presenting with 46,XY DSD and hypospadias. Based on their clinic...

OBJECTIVE Few studies of hypospadias repair in childhood have used validated questionnaires to investigate outcomes of cosmesis, urinary function, and sexual function in adulthood. We sought to investigate long-term outcomes in adult patients who had undergone severe hypospadias repair as children using an existing web-based application available to multiple institutions in order to develop an ...

What defines ‘severe’ hypospadias? The authors describe those having ‘proximal division of the corpus spongiosum’, but others might consider penoscrotal to perineal hypospadias the ‘severe’ cases, while another definition in this era of urethral plate-based urethroplasty might be those whose ventral curvature leads to plate transection. Less ambiguous terms are needed for surgeons to clearly co...

Objective: The aim of this study is to assess whether repairing hypospadias before or after 18 months affects psychological adjustment, health-related quality of life (HRQoL) and surgical outcome. Subjects/Patients 77 boys with a current age of 6 to 17 years were assigned to two groups, according to whether they had a hypospadias repair before or after the age of 18 months. The surgical outcome...

OBJECTIVE To assess whether repairing hypospadias before or after 18 months affects psychological adjustment, health-related quality of life (HRQoL) and surgical outcome. PATIENTS AND METHODS Seventy-seven boys aged 6-17 years were assigned to one of two groups, according to whether they had a hypospadias repair before or after the age of 18 months. The surgical outcome was assessed using the...

Hypospadias is treated surgically and different methods can useable for this way. Due to involuntary erections during adolescence later, neourethra seems at risk until wound healing complete. Erections following penile surgery are painful affect the process negatively, because stitches may not withstand a strong erection. Therefore, prevention of erection management pain extremely important aft...

OBJECTIVE Hypospadias is a frequent congenital anomaly but in most cases an underlying cause is not found. Steroidogenic factor 1 (SF-1, NR5A1, Ad4BP) is a key regulator of human sex development and an increasing number of SF-1 (NR5A1) mutations are reported in 46,XY disorders of sex development (DSD). We hypothesized that NR5A1 mutations could be identified in boys with hypospadias. DESIGN A...

BACKGROUND Animal models of endocrine dysfunction have associated male genital defects with reduced anogenital distance (AGD). Human studies have correlated shorter AGD with exposure to putative endocrine disruptors in the environment but have not examined AGD in hypospadiac boys. We measured AGD in boys with hypospadias and those with normal genitals. METHODS Data were collected prospectivel...

OBJECTIVE To evaluate the factors that may influence the results of surgery after hypospadias repair at National Institute of Child Health, Karachi. METHODS It was a retrospective observational study. Files of all patients who had Hypospadias repair were retrieved and analysed with a view to identify the factors which may influence the results of surgery for Hypospadias. Patients with complet...

hypospadias is an uncommon congenital defect of urinary tract in farm animals. this defect has been recorded rarely in calves, lambs and foals in the world. the aetiology of hypospadias is not well understood, it seems to be multifactorial and may be related to genetic, endocrinological, and environmental factors. during april to october 2007, twenty-four goat kids with sings of hypospadias wer...