a highly efficient and simple method for the preparation of α,α´-bis(arylidene)cycloalkanones under solvent-free conditions has been developed. the crossed-aldol condensation of cycloalkanones (1 eq.) with arylaldehydes (2 eq.) in the presence of 2.5 mol% of ionic liquid 1,3-disulfonic acid imidazolium hydrogen sulfate {[dsim]hso4} afforded the title compounds in high yields and short reaction ...

efficient and one-pot synthesis of 1,8-dioxo-octahydroxanthenes was described by knoevenagel condensation, michael addition and cyclodehydration of dimedone. this reaction was carried out through condensation of dimedone and various aromatic aldehydes in the presence of task-specific brønsted acidic ionic liquid under solvent free conditions. the catalyst could be recycled five times without si...

In the combination of 5-fluorophenyl-1, 3, 7, 9-tetra methyl pyrido [2, 3, d, d, 5, 6 di pyrimidine -2, 4, 6, and 8 tetron, there are 4 rings, respectively, ring that is attached to the halogen ring A and, respectively, a ring The lower and the right to the left of the ring A are called C, B, and D. Calculations and studies show that the amount of aromatics in halogen-ring A in all cases has th...

The relevance of security as one of the major contributors to an effective operational infrastructure has been growing in importance over the past 3-5 years, and today it resides as one of the two top investment priorities for senior management (the other one being critical server virtualization). Effective management by organizations when dealing with targeted and multiple parallel attacks com...

objective: vitamin d deficiency is a common disorder worldwide and is indicated by low serum 25-hydroxyvitamin d levels. recent studies have suggested an association of 25-hydroxyvitamin d deficiency with diabetes mellitus. the objective of this study is to investigate the relationship between 25-hydroxyvitamin d concentration and type 2 diabetes in south indian patients. materials and methods:...

an efficient and convenient protocol for synthesis of 3-hydroxy-3-indolyl-2-oxindoles and 3,3-diindolyl-2-oxindoles is presented here. the syntheses were achieved selectively under catalysis of liclo4 whereby the products were obtained purely.