We propose an unsupervised methodology using independent component analysis (ICA) to cluster genes from DNA microarray data. Based on an ICA mixture model of genomic expression patterns, linear and nonlinear ICA finds components that are specific to certain biological processes. Genes that exhibit significant up-regulation or down-regulation within each component are grouped into clusters. We t...

To study the effects of myocardial hypertrophy resulting from chronic pressure overload on excitation-contraction coupling, the cardiac transmembrane L-type calcium current (ICa) was investigated in the Goldblatt renovascular hypertensive (HBP) rat. ICa was measured in single myocytes enzymatically isolated from control (CTRL) and HBP rat hearts using the whole-cell, patch-clamp method. The pea...

BACKGROUND Independent component analysis (ICA) has been often used to decompose fMRI data mostly for the resting-state, block and event-related designs due to its outstanding advantage. For fMRI data during free-listening experiences, only a few exploratory studies applied ICA. NEW METHOD For processing the fMRI data elicited by 512-s modern tango, a FFT based band-pass filter was used to fu...

BACKGROUND AND OBJECTIVES Abdominal Aortic Aneurysm (AAA) and carotid disease have medical and social significance, considering their morbidity, disability, and economic consequences. The study objectives were to determine the prevalence of asymptomatic internal carotid artery (ICA) lesions ≥70% in patients with AAA, the correlation of AAA diameter with the degree of ICA stenosis and symptoms, ...

In this paper, independent component analysis (ICA) is used for blind source separation of biomedical signals. Visual and quantitative tests of the ability of ICA to separate signals were performed using a fast ICA algorithm. Results obtained from simulated and FECG signals show that the ICA performance using the whitening matrix of the mixed signals was superior to that of random initial weights.

BACKGROUND Large artery atherosclerosis is a major cause of ischemic stroke worldwide. Differential biomarker profiles associated with extra- and intracranial atherosclerosis are a topic of considerable interest. Cystatin C (CysC), a marker of renal function, is a risk factor for cardiovascular disease. AIM We sought to determine whether CysC levels were associated with extra- and intracrania...

Abstract Introduction The SYNTAX III REVOLUTION trial demonstrated that clinical decision-making between coronary artery bypass graft (CABG) and percutaneous intervention (PCI) based on computed tomography (CCTA) predicting four years mortality according to the score II had a high agreement with treatment decision derived from invasive angiography (ICA). of novel 2020 (SS-2020) CCTA ICA has not...

• Invasive coronary angiography was performed in high risk transplant candidates. Multidisciplinary decision on listing for and revascularisation. 169 patients listed underwent angiography, 73 had artery disease. Coronary disease did not affect 5-year survival post-transplant. Cardiovascular assessment is central to evaluation of liver (LT) However, there a lack consensus the diagnostic algorit...

A traumatic internal carotid artery (ICA) aneurysm is rare and difficult to treat. Trapping of ICA is commonly performed owing to the difficulty of directly approaching ICA aneurysms. Recently, coiling the aneurysm itself was recommended if possible. However, it is controversial which of methods are best to completely treat aneurysm. We present the case of a 74-year-old man, who had experienced...

OBJECTIVE To test the hypothesis that glucose ingestion leads to a decrease in plasma ionized calcium (iCa) and ionized magnesium (iMg) during the third trimester of pregnancy. METHODS We studied 54 women who underwent a 50 g glucose challenge test (GCT) and 27 women who underwent a 3-hour 100 g glucose tolerance test (GTT) because of an abnormal GCT. Plasma glucose was measured with an autom...