The NF-E2 related factor 2 (Nrf2) could be activated in intracerebral hemorrhage (ICH), and trigger the expression of ARE regulated heme oxygenase 1 (HO-1) subsequently. This study aims to explore neuroprotection of HO-1 protein in regulating the Nrf2-ARE signaling pathway in ICH. In this study, the femoral artery injection method was used to establish the ICH model. The zinc porphyrin-9 (ZPP-I...

BACKGROUND AND PURPOSE Various grading scores to predict survival after intracerebral hemorrhage (ICH) have been described. We aimed to test the accuracy and clinical usefulness of 3 well-known scores (original ICH score, modified ICH score, and ICH grading scale) in a large unselected cohort of typical ICH patients. METHODS A total of 1364 ICH cases were referred to our center from January 1...

Spontaneous intracerebral haemorrhage (ICH) is defined as a collection of blood in the cerebral parenchyma that is not caused by trauma. ICH is the second most frequent cause of stroke, accounting for 10–15 % of all cases in high-income countries and about 20 % in lowto middle-income countries. Despite an apparent stability of incidence over the past decades, the profile of ICH has changed: the...

BACKGROUND: Adipokines and inflammatory factors play an important role in disease progression. Two cardiovascular diseases which have important contributions to mortality and morbidity in China are intracerebral hemorrhage (ICH) and myocardial infarction (MI). Acylation stimulating protein has been shown in North American populations to have strong associations with risk factors for MI. Complem...

BACKGROUND Stroke outcome studies often combine cases of intracerebral hemorrhage (ICH) and ischemic stroke (IS). These studies of mixed stroke typically ignore computed tomography (CT) findings for ICH cases, though the impact of omitting these traditional predictors of ICH mortality is unknown. We investigated the incremental impact of ICH CT findings on mortality prediction model performance...

In this paper we show how to interpret Robinson’s Arithmetic Q and the theory R of Tarski, Mostowski and Robinson as theories of cardinals in very weak theories of relations over a domain. Bei der Verfolgung eines Hasen wollte ich mit meinem Pferd über einen Morast setzen. Mitten im Sprung musste ich erkennen, dass der Morast viel breiter war, als ich anfänglich eingeschätzt hatte. Schwebend in...

See related article, page 67. The study by Garg et al1 reports the frequency of decreased diffusion using diffusion-weighted imaging and an apparent diffusion coefficient map in patients with intracerebral hemorrhage (ICH) undergoing MRI. Only areas of decreased diffusion that were not contiguous with the hematoma were analyzed. A total of 36 (38%) of 95 patients with ICH had evidence of decrea...

OBJECTIVE To characterize the rates of recurrent intracranial hemorrhage (ICH), ischemic stroke, and death in survivors of primary ICH. METHODS Systematic review of studies reporting recurrent stroke in survivors of primary ICH, identified at index ICH and followed forward. Studies were identified by computerized search of the literature and review of reference lists. RESULTS Ten studies pu...

BACKGROUND AND PURPOSE The effect of obesity on the risk of intracerebral hemorrhage (ICH) may depend on the pathophysiology of vessel damage. To further address this issue, we investigated and quantified the correlations between obesity and obesity-related conditions in the causal pathways leading to ICH. METHODS A total of 777 ICH cases ≥ 55 years of age (287 lobar ICH and 490 deep ICH) wer...

Objective: Intracranial hemorrhage (ICH) after endovascular revascularization (ER) for acute ischemic stroke is associated with poor outcome. In this study, we examined the risk factors for postoperative ICH in patients who underwent ER in our hospital. Methods: We investigated the incidence/type of postoperative ICH and risk factors in 157 patients who underwent ER in our hospital from July 20...