نتایج جستجو برای: idarubicin
تعداد نتایج: 767 فیلتر نتایج به سال:
BACKGROUND Initial therapy for patients with acute promyelocytic leukemia most often involves the combination of all-trans-retinoic acid with anthracycline-based chemotherapy. The role of non-anthracycline drugs in induction and consolidation is less well-established and varies widely between different cooperative group protocols. DESIGN AND METHODS In an attempt to minimize relapse and maxim...
(waf1/cip1) p53, tumour suppressor protein 53; This article has not been copyedited and formatted. The final version may differ from this version. Abstract We recently reported induction of UGT2B7 by its substrate epirubicin, a cytotoxic anthracycline anticancer drug, via activation of p53 and subsequent recruitment of p53 to the UGT2B7 promoter in hepatocellular carcinoma HepG2 cells. Using th...
OBJECTIVE To evaluate the efficacy and toxicity profile of the combination of fludarabine, high dose cytarabine, idarubicin, and granulocyte colony stimulating factor in refractory relapsed cases of acute leukaemia, a study is being conducted at Armed Forces Bone Marrow Transplant Centre (AFBMTC) Rawalpindi since January 2003. Data up to June 2004 (early report) is being presented. METHODS Tw...
Relapsed/refractory acute myeloid leukemia (R/R-AML) is characterized by a high incidence, short survival and poor prognosis. Presently, no unified effective reinduction chemotherapy regimen has been developed. Therefore, the use of regimens before allogeneic hematopoietic stem cell transplantation (allo-HSCT) controversial. Our study aims to analyze prognostic factors R/R-AML evaluate efficacy...
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