Both systemic and organ-specific autoimmune diseases are major manifestations of IgA deficiency (IgAD), the most common primary immunodeficiency In addition to 14 . , discuss the clinical findings of IgAD patients, we proposed a hypothesis to explain the high association with autoimmune phenomena. Assessment of Intestinal Barrier Permeability to Large Antigenic Molecules Aristo Vojdani, Ph.D., ...

Although IgA deficiency (IgAD) is currently recognised as the most frequent immunodeficiency in humans, individuals with IgAD are largely considered to be healthy and when discovered are usually not investigated further or followed up. The rare occasion when IgAD is a cause for concern is when these individuals require blood or blood products, in which case current practice advises that product...

A young woman developed Hodgkin's disease (nodular sclerosis) in pregnancy and gave birth to a boy who developed common variable immunodeficiency. Initially there was normal IgG with low IgA and IgM, and antibody deficiency. IgG levels fell progressively over 4 years. Cellular immunity was normal. We suggest that this is a further family with immune deficiency presenting with common variable im...

Selective immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in Caucasians. It has previously been suggested to be associated with a variety of concomitant autoimmune diseases. In this review, we present data on the prevalence of IgAD in patients with Graves disease (GD), systemic lupus erythematosus (SLE), type 1 diabetes (T1D), celiac disease (CD), myasthenia gravi...

Objective. To study NETosis parameters in patients with selective immunoglobulin A deficiency. Material and methods. We studied the features of peripheral blood 46 (21 males 25 females, mean age 37±12.7 years) a confirmed diagnosis Results. Аctivation (NET30SP, NET30ST, NET150SP NET150ST, р<0.001) was found IgA deficiency relative to comparison group. The maximum degree increase leukocyte ob...

We have previously shown that human B lymphocytes cultured in the CD40 system, composed of an anti-CD40 mAb presented by a CD32-transfected fibroblastic cell line, proliferate but do not secrete antibodies. However, the addition of particles of Staphylococcus aureus Cowan (SAC) induces B cell differentiation even in the absence of exogenous cytokines (CD40/SAC system). Additionally, B lymphocyt...

We have previously shown that human B lymphocytes cultured in the CD40 system, composed of an anti-CD40 mAb presented by a CD32-transfected fibroblastic cell line, proliferate but do not secrete antibodies. However, the addition of particles of Staphylococcus aureus Cowan (SAC) induces B cell differentiation even in the absence of exogeneous cytokines (CD40/SAC system). Additionally, B lymphocy...

We have previously shown that human B lymphocytes cultured in the CD40 system, composed of an anti-CD40 mAb presented by a CD32-transfected fibroblastic cell line, proliferate but do not secrete antibodies. However, the addition of particles of Staphylococcus aureus Cowan (SAC) induces B cell differentiation even in the absence of exogeneous cytokines (CD40/SAC system). Additionally, B lymphocy...

Studies have implicated defective Ig class switch in the pathogenesis of IgA deficiency. To understand better the molecular events that regulate IgA class switch, a 1.4-kb region of the IgA locus containing the I alpha exon was replaced with a human hypoxanthine phosphoribosyltransferase minigene by gene targeting in murine embryonic stem cells. The I alpha exon-deficient mice derived from thes...