Platelet-activating factor (PAF), a potent signaling lipid implicated as a mediator of pathological responses, has both negative chronotropic and inotropic effects on the heart, although the mechanism(s) involved is not well defined. Because activation of the muscarinic acetylcholine-activated K+ current (IK(ACh)) also produces a negative chronotropic and inotropic response in myocardium, this ...

Current views of sustainable development recognize the importance of accepting the Indigenous Knowledge (IK) of rural people. However, there is an increasing technological gap between Elder IK holders and the younger generation and a persistent incompatibility between IK and the values, logics and literacies embedded, and supported by ICT. Here, we present an evaluation of new technology that m...

The effect of cal-adrenoceptor stimulation on the delayed rectifier K' current (IK) was examined in isolated guinea pig ventricular cells by use of the patch-clamp method. 'K was evoked by a 3-second depolarizing pulse from a holding potential of -30 mV in a Na+and K'-free solution containing 3 ,uM nifedipine. Phenylephrine (30 ,uM) in the presence of propranolol (1 ELM) produced an increase in...

The prosomatostatin-derived peptides somatostatin-14 (Som-14) and somatostatin-28 (Som-28) are believed to act as neurotransmitters in the central nervous system. To examine possible mechanisms by which these peptides induce their physiological actions in brain, the effects of Som-14 and Som-28 on voltage-dependent K+ currents in rat cerebral cortical neurons in culture were examined by using w...

Constitutive activation of the transmembrane receptor, Notch3, and loss of function of the hematopoietic transcription repressor, Ikaros (IK), play direct roles in T-cell differentiation and leukemogenesis that are dependent on pre-T-cell receptor (pre-TCR) signaling. We demonstrate the occurrence of crosstalk between Notch3 and IK that results in transcriptional regulation of the gene encoding...

Major liver resection is associated with impaired intestinal perfusion and intestinal ischemia, resulting in decreased mucosal integrity, increased bacterial translocation, and an increased risk of postoperative sepsis. However, the mechanism by which ischemia impairs intestinal mucosal integrity is unclear. We therefore evaluated the role of Ca(2+)-sensitive, intermediate-conductance (IK(Ca)) ...

Block of the delayed rectifier potassium current, IK, by the class IC antiarrhythmic agent, flecainide, and by the novel selective class III antiarrhythmic agent, E-4031, were compared in isolated cat ventricular myocytes using the single suction-pipette, voltage-clamp technique. Flecainide (10 jiM) markedly reduced IK elicited on depolarization steps to plateau voltages (+10 mV) and nearly com...

We study a non-anticommutative chiral non-singlet deformation of the N =(1, 1) abelian gauge multiplet in Euclidean harmonic superspace with a product ansatz for the deformation matrix, C (αβ) (ik) = c (αβ) b (ik). This choice allows us to obtain in closed form the gauge transformations and the unbroken N =(1, 0) supersymmetry transformations preserving the Wess-Zumino gauge, as well as the bos...

LiI(x1, . . . , xn) = AI(∞;x1, . . . , xk) are called multiple polylogarithms [2]: they generalize the classical polylogarithm Lin(x1) = A(n)(∞;x1). It is immediate from the defining equations (1) and (2) that the sums SI can be written in terms of the AI . To state the relation precisely, let C(n) be the set of compositions of n, i.e., ordered sequences (i1, . . . , ik) of positive integers wi...