Abstract Background and Aims Systemic lupus erythematosus (SLE) is an autoimmune disease directed against nuclear antigens, including those derived from apoptotic microparticles (MPs) neutrophil extracellular traps (NETs). Innate immune cells display hyperreactive phenotype in patients with SLE, increased expression of immunostimulatory surface markers production proinflammatory cytokines. We h...

In the present study, ethanolic extract of Mesua ferrea L. stamens was investigated for its potential to reverse some features bronchial asthma in ovalbumin-induced murine model asthma. commonly called nagakeshar (Family, Calophyllaceae) is a well-known antiallergic drug Asian folk system medicines. work, pharmacological studies are done provide scientific evidence therapeutic plants allergic A...

objective: astrocytes are the most abundant glial cell type. they may promote or inhibit cns inflammation depending on which cytokines are secreted. astrocytes also have immune roles. il-19, il-20, and il-24 activate a heterodimer receptor composed of the il-20r1 α-chain and the il-20r2 β-chain. it has long been considered that signaling by these receptor complexes affects immunological reactio...

This study tested the hypothesis that combined therapy with exendin-4 (Ex4) and autologous adipose-derived mesenchymal stem cells (ADMSCs) was superior to either alone for protecting renal function against acute kidney ischemia-reperfusion (IR; 40-min ischemia/27-h reperfusion) injury when complicated by sepsis syndrome (SS; by cecal-ligation-puncture). Adult-male Sprague-Dawley rats (n=40) wer...

OBJECTIVE Recent studies have shown that activation of the immune system, inflammatory cell infiltration, and activation of inflammatory mediators play an important role in the development of heart failure. The purpose of this study was to investigate whether cardiac function can be improved by regulating the balance of lymphocyte subsets and cytokines. METHODS Ninety-six patients with chroni...

BACKGROUND The association of eosinophils with inflammation and tissue remodeling is at least partially due to their release of toxic granule proteins and other mediators, including cytokines. Tissue remodeling and consequent functional defects are affected by activity of connective tissue fibroblasts. Exaggerated fibroblast activation, accumulation and change of phenotype may lead to fibrosis ...

729 AN INFLAMMATORY STATE IS KNOWN TO EXIST IN SLEEP DISORDERS.1,2 INTERLEUKIN-6 (IL-6), FOR EXAMPLE, IS AN INFLAMMATORY CYTOKINE THAT IS elevated in sleep apnea and narcolepsy.3-5 Better sleep is associated with decreased daytime secretion of IL-6, whereas disturbed nocturnal sleep is associated with increased daytime IL-6 levels.6 Other markers of inflammation, including plasma endothelin-1 (...

Gastrointestinal epithelial barrier loss due to tight junction (TJ) dysfunction and bile acid-induced diarrhea are common in patients with inflammatory diseases. Although excess colonic bile acids are known to alter mucosal permeability, few studies have compared the effects of specific bile acids on TJ function. We report that the primary bile acid, chenodeoxycholic acid (CDCA), and its 7α-deh...

Purpose: In the present study, the effects of verapamil on inflammation and angiogenesis in air pouch model were studied. Methods: To create a model of inflammation in the rats, on days 1 and 3 sterile air, and on the sixth day, carrageenan was injected into the pouch subcutaneously. Normal saline as control, diclofenac sodium and dexamethasone as standards and verapamil (0.05, 0.1 and 0.2mg/ra...