The present study investigated the role of IL-10 produced by the mesangial cells in postnephrectomy compensatory renal growth and the effect of the immunomodulator AS101 on this process. One hundred forty unilateral nephrectomized and sham-operated male Sprague-Dawley rats were treated by AS101 or PBS before and after surgery. The results show that secretion of IL-10 and TGF-beta by mesangial c...

Background: Multiple sclerosis (MS) is known as a progressive central nervous system inflammatory disease. Certain factors, such as interleukins, inflammatory cells, and oxidative stress are supposed to involve in MS etiology. Because of the important role of oxidative stress, antioxidant therapy for MS has received more attention. Although coenzyme Q10 (CoQ10) acts as an antioxidant, there is ...

Abstract Background COVID-19 has spread widely worldwide, causing millions of deaths. We aim to explore the association immunological features with severity. Methods conducted a meta-analysis estimate mean difference (MD) immune cells and cytokines levels severity in PubMed, Web Science, Scopus, Cochrane Library grey literature. Results A total 21 studies 2033 patients were included. Compared m...

The aim of our research was to obtain new minimally invasive serum markers fibrotic changes liver in patients with chronic diffuse diseases different etiology and compare them traditional markers. 364 aged 30 66 years were examined: 221 women (60.7%) 143 men (39.3%). Depending on the etiological factors, all divided into 4 groups: group I consisted 108 non-alcoholic fatty disease (NAFLD), II – ...

White adipose tissue (WAT) is the source of proand antiinflammatory cytokines and recently, it recognized as an important source of interleukin 10 production (IL-10). Acute physical exercise induce an anti-inflammatory cytokine profile. However, the effect of chronic physical exercise in the production of IL-10 by the WAT has never been examined. IL-10 and TNF-α were assessed in WAT of rats eng...

MRL/MpJ-Tnfrsf6(lpr) (MRL/MpJ-Fas(lpr); MRL-Fas(lpr)) mice develop a spontaneous lupus syndrome closely resembling human systemic lupus erythematosus. To define the role of IL-10 in the regulation of murine lupus, IL-10 gene-deficient (IL-10(-/-)) MRL-Fas(lpr) (MRL-Fas(lpr) IL-10(-/-)) mice were generated and their disease phenotype was compared with littermates with one or two copies of an int...

We conducted a case-control study to clarify the asso-ciations between inflammatory cytokine, including interleukin (IL)-1b, IL-6, IL-8, and IL-10, polymorphisms and risk of acute pancreatitis. Genotyping analyses of IL-1β+3954 C/T (rs1143634), IL-1β-511 C/T (rs16944), IL-6 -174 G/C (rs1800795), IL-6 -634 C/G (rs1800796), IL-8 -251T/A (rs4073), IL-10 -1082A/G (rs1800896), and IL-10 -819C/T (rs1...

We examined the possible role of hydrogen sulfide (H2S) in the pathogenesis of oleic acid (OA)-induced acute lung injury (ALI) and its regulatory effects on the inflammatory response. Compared to control rats, the OA-treated rats had decreased partial pressure of oxygen in the arterial blood (PaO2) levels, an increased pulmonary wet/dry weight (W/D) ratio, increased index of quantitative assess...

BACKGROUND The contribution of local and systemic inflammation to the pathophysiology of sporadic first trimester miscarriages remains unclear. The objective of this study was to investigate the inflammatory response in the circulation of women presenting with first trimester miscarriage. METHODS Levels of tumour necrosis factor alpha (TNFα), TNF receptors 1 and 2, interferon gamma (IFNγ), in...