I read with interest the article by de Buck van Overstraeten et al., ‘Intersphincteric proctectomy with end-colostomy for anorectal Crohn's disease (CD) results in early and severe proximal colonic recurrence’.1 In their case series, 10 consecutive patients underwent intersphincteric proctectomy with end-colostomy. Early symptomatic recurrence occurred in 9 of the 10 patients at a median follow...

BACKGROUND Patients with ankylosing spondylitis (AS) are at increased risk of developing inflammatory bowel disease (IBD). We aimed to determine the variation in fecal calprotectin in AS over 5 years in relation to disease activity and medication and also to study the incidence of and predictors for development of IBD. METHODS Fecal calprotectin was assessed at baseline (n = 204) and at 5-yea...

Hyperimmunoglobulinemia D is the less severe form of mevalonate kinase deficiency (MKD) caused by recessive inherited mutation in the mevalonate kinase gene. Hyperimmunoglobulinemia D is characterized by febrile attacks, often associated with transient digestive manifestations, such as abdominal pain, diarrhea, and vomiting. Here we report for the first time 2 patients with MKD revealed by seve...

Background and aims: Recently, magnetic resonance imaging (MRI) has been introduced in the diagnosis of patients with inflammatory bowel disease (IBD). However, it is still rarely reported in paediatric IBD. We studied the diagnostic value of gadolinium enhanced MRI in revealing inflammation of the distal ileum in children with Crohn’s disease (CD) and in differentiating them from patients with...

Here we would like to share our first experience of a paediatric patient with refractory ulcerative colitis [UC] successfully treated with vedolizumab. A 13-year-old boy presented at our outpatient clinic with abdominal pain, bloody diarrhoea, and weight loss. Ileocolonoscopy showed a continuous colitis extending throughout the entire colon [Mayo endoscopic score 3], with no abnormalities seen ...

BACKGROUND In recent years, the use of MRI in patients with Crohn's disease (CD) has increased. However, few data are available on how MRI parameters of active disease change during treatment with anti-TNF and whether these changes correspond to symptoms, serum biomarkers, or endoscopic appearance. The aim of this study was to determine the changes over time in MRI parameters during treatment w...

Objectives—A role for Klebsiella pneumoniae in ankylosing spondylitis (AS) has been suggested because faecal carriage of Klebsiella and serum Klebsiella specific antibodies may be increased in this disease. This study has extended the earlier findings by comparing Klebsiella specific serum IgA class antibodies with inflammatory changes in the gut. Methods—IgA antibodies to K pneumoniae, Escheri...

The majority of patients suffering from Crohn’s disease will undergo at least one surgical resection of the bowel in the course of their disease. Surgery greatly improves the quality of life in these patients but the beneficial effect is only temporary. After ileal or ileocolonic resection there is a 20–30% symptomatic recurrence rate in the first year after surgery, with a 10% increase in each...

This year, at the Annual Meeting of the American Academy of Neurology, the inaugural session of the “Autoimmune Neurology” section was held. Attendance and enthusiasm were high. The term “Autoimmune Neurology” is currently used to describe the emerging field that encompasses “immune-inflammatory” diseases of the nervous system other than MS. Autoimmune Neurology has emerged over the past 15 yea...

We read with interest the paper by Taylor et al.1Taylor K.M. al.Clin Gastroenterol Hepatol. 2020; 18: 908-916Abstract Full Text PDF PubMed Scopus (12) Google Scholar The authors calculated a risk score for asymptomatic first-degree relatives (FDR) of patients Crohn's disease (CD) combining genetic (a synthesis 72 CD variants) and smoking status. Such was used to identify FDRs in lowest highest ...