PURPOSE Gastric cancer and its premalignant gastric lesion, intestinal metaplasia (IM), frequently express cyclooxygenase-2 (COX-2) at high levels. We tested whether long-term use of specific COX-2 inhibitors regress gastric IM. EXPERIMENTAL DESIGN This is a double-blind, randomized, placebo-controlled trial. Individuals with confirmed IM and Helicobacter pylori clearance were randomized to r...

The intermediate mesoderm (IM) is the embryonic source of all kidney tissue in vertebrates. The factors that regulate the formation of the IM are not yet well understood. Through investigations in the chick embryo, the current study identifies and characterizes Vg1/Nodal signaling (henceforth referred to as 'Nodal-like signaling') as a novel regulator of IM formation. Excess Nodal-like signalin...

Instant messaging (IM) has become one of the most popular forms of computer-mediated communication (CMC) and is especially prevalent on college campuses. Previous research suggests that IM users often multitask while conversing online. To date, no one has yet examined the cognitive effect of concurrent IM use. Participants in the present study (N = 69) completed a reading comprehension task uni...

Most types of electrical machines such as Induction Motors (IMs) can be modeled by an equivalent 2-phase machine (d-q model). For instance a single-phase IM with two main and auxiliary windings can be modeled as an equivalent 2-phase IM. Also a faulty single-phase IM (single-phase IM under open-phase fault) can be modeled as an unbalanced 2-phase IM. This study confirms this concept by modeling...

BACKGROUND Gastric epithelial hyper-proliferation was reported in patients with Helicobacter pylori (H. pylori)-infected gastric mucosa with intestinal metaplasia (IM) changes. In patients with gastric ulcer (GU) and IM, the GU may have a different healing rate in comparison to patients without IM. This study aimed to compare the difference in GU healing between H. pylori-infected patients with...

Imatinib mesylate (IM) is a small molecule inhibitor of protein tyrosine kinases. In addition to its direct effect on malignant cells, it has been suggested IM may activate of natural killer (NK) cells, hence exerting immunomodulatory functions. In preclinical settings, improved antitumor responses have been observed when IM and interleukin-2 (IL-2), a cytokine that enhances NK cells functions,...

Autophagy is a bulk degradation system mediated by biogenesis of autophagosomes under starvation conditions. In Saccharomyces cerevisiae, a membrane sac called the isolation membrane (IM) is generated from the pre-autophagosomal structure (PAS); ultimately, the IM expands to become a mature autophagosome. Eighteen autophagy-related (Atg) proteins are engaged in autophagosome formation at the PA...

BACKGROUND The Infobutton Manager (IM) is an application that provides clinical users with context-specific links to health information resources. Usage of the first version (IM-1) suggested that the user interface was suboptimal. METHODS We conducted a laboratory-based observational study of IM-1, use, applied standard user interface design techniques to address observed problems, developed ...

Aktuelle Forschungsaktivitäten im Bereich der Datenstromverarbeitungssysteme untermauern die zunehmende Bedeutung von Datenströmen, etwa im Kontext von Sensornetzwerken und im Bereich e-Science. Mit der zunehmenden weltweiten Vernetzung experimentell arbeitender Wissenschaftler ist die Entwicklung von Datenstrom-ManagementSystemen (DSMS) zur Informationsgewinnung aus im Netz veröffentlichten Me...

Research on computer-mediated communication (CMC) has thus far largely overlooked instant messaging (IM), an extremely popular, and increasingly important, form of CMC. This study examines the most prevalent motivations for using IM within what is currently among the largest demographic groups utilizing this tool, college students. Data from 271 students are used to assess current motivations f...