Epidemiological studies suggest that increased intake of the omega-3 (n-3) polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) is associated with reduced risk of Alzheimer's disease (AD). DHA levels are lower in serum and brains of AD patients, which could result from low dietary intake and/or PUFA oxidation. Because effects of DHA on Alzheimer pathogenesis, particularly on amyloidosis...

We present a concept called ‘ubiquitous attentiveness’: Context information concerning the user and his environment is aggregated, exchanged and constitutes triggers that allow mobile applications and services to react on them and adapt accordingly. Ubiquitous attentiveness is particularly relevant for mobile applications due to the use of positional user context information, such as location a...

It is estimated that as many as 25 percent of individuals living with autism spectrum disorders are nonverbal. That is, they cannot functionally communicate with others using their voice. Despite that substantial fraction, we still know very little about these individuals, their abilities, and their needs. "We still know very little about the cognitive capabilities of nonverbal people with auti...

The desire to develop new point-of-care (POC) diagnostic tools has led to the adaptation of smartphones to tackle limitations in state-of-the-art instrumentation and centralized laboratory facilities. Today's smartphones possess the computer-like ability to image and process data using mobile apps; barcode scanners are one such type of apps. We demonstrate herein that a diagnostic assay can be ...

The purpose of this paper is to introduce a fast automated whitenoise estimation method which gives reliable estimates in images with smooth and textured areas. This method is a block-based method that takes image structure into account and uses a measure other than the variance to determine if a block is homogeneous. It uses no thresholds and automates the way that blockbased methods stop the ...

APP-BP1, first identified as an amyloid precursor protein (APP) binding protein, is the regulatory subunit of the activating enzyme for the small ubiquitin-like protein NEDD8. We have shown that APP-BP1 drives the S- to M-phase transition in dividing cells, and causes apoptosis in neurons. We now demonstrate that APP-BP1 binds to the COOH-terminal 31 amino acids of APP (C31) and colocalizes wit...

The increasingly ageing population is an important issue for family relationships. If the human-device interface is well designed, older citizens can manage icons more easily than typing on a keyboard. The authors use the design of experiment method to evaluate the effect of App games. There are 2*2*2=8 combinations in the experiment. The three factors are image size, touch guidelines and degre...