In the present work a series of novel 2,4-disubstituted -1, 5 -diphenyl substituted -1H-imidazole derivatives were screened for anticancer activity using human liver cancer cell line. Derivatives were evaluated for anticancer activities against Hep G2 (Human liver cancer) cell lines. Newly synthesized compounds A-IVn, A-IVo,B-IVb, B-IVc, B-IVd, and B-IVe showed highly significant cytotoxic acti...

Reaction of 1-(3-cyanopropoxy)-3,4-dihydronaphthalene-2-carbonitriles with potassium tert-butoxide gave 5-amino-1,2,6,7-tetrahydrobenzo[f]furo[2,3-c]isoquinolines via a Truce-Smiles rearrangement. The 5-amino group was transformed to the bromo derivatives which were allowed to react with aliphatic cyclic amines to produce amino derivatives. In contrast, a combination of imidazole and NaH gave a...

The imidazole moiety finds itself in a host of compounds having profound biological and medicinal properties. This has led to the quest develop cost effective, desirably greener synthetic route access this azole. In review, ultrasonic irradiation assisted syntheses trisubstitued derivatives have been discussed which make use different environment friendly efficient catalytic systems. They found...

Two different transformations of α-(isochromen-1-yl)ketones catalyzed by NHC Brønsted bases are reported. In the presence of a triazole carbene, α-(isochromen-1-yl)ketones isomerized into β-(2-(aroylmethylene)phenyl)-α,β-unsaturated ketones in 38-88% yields, while the same reaction catalyzed by an imidazole carbene produced 1-aroylnaphthalene derivatives in 90-99% yields. This work not only pro...

Medicinal chemistry deals with study of structure and synthesis of drugs and there action of the body that is lots of works is done in clubbing of the molecules to get new pharmacological active drugs. In today’s world of medicine we was tried to produced a novel and potent drug which was having verity of activities and stable motiy our emphasis to prepared simple and potent moties in world of ...

The specific affinity for membrane lipids and the membrane selectivity of three imidazole derivatives, clotrimazole, miconazole, and econazole, were studied using various types of liposomes with respect to the lecithin fatty acyl group composition and the liposome content and composition of sterol as membrane models. The sensitivity of liposomes to these drugs was primarily dependent upon the l...