Syntheses of various classes of fused-imidazoles are reported. The key to their successful synthesis depends on the reaction of N-vinyl-1H-imidazole with the π-deficient compounds under basic conditions. Reaction of the target imidazole with 1,1,2,2-tetracyanoethylene and dimethyl acetylenedicarboxylate afforded pyrrolo[1,2-a]imidazoles. On the other site, reaction of the target imidazole with ...

Kaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, anti...

Kaolin-SO3H as a new solid acid is prepared via reaction of kaolin and chlorosulfonic acid. This natural based catalyst is very inexpensive and easy available. Imidazoles are an important class of heterocycles being the core fragment of different natural products and biological systems such as anti-allergic, anti-inflammatory, analgesic, antifungal, antimycotic, antibiotic, antiulcerative, anti...

Abstract: Background: Search for the better anti-cancer agents become central part many research teams as current drugs in use suffer lack of specificity to cancer targets. Design and development target specific increase potency safety drugs. Materials Methods: Current intends develop a novel series pyrimidine derivatives owing potential scaffold. In multicomponent reaction approach, 4,5-disubs...

Land multicomponent seismic has garnered significant attention and demonstrated substantial growth in the last five years. The bulk of this growth in multicomponent activity has been in western Canada. While multicomponent seismic has been around for many years, historical cost and quality concerns have limited its use as a routine exploration tool. The current resurgence of multicomponent seis...

A facile and novel synthesis of thirteen 2-amino-3-cyanopyridine derivatives 5(a–m) by a one-pot multicomponent reactions (MCRs) is described for the first time, starting from aromatic aldehydes, malononitrile, methyl ketones, or cyclohexanone ammonium acetate in presence nanostructured diphosphate Na2CaP2O7 (DIPH) at 80 °C under solvent-free conditions. These compounds were brought into existe...

Two multicomponent crystalline phases of (S)-ibuprofen and l-proline with 1:1 stoichiometry are reported, specifically a nonsolvate phase (Ibu-Pro) quarter-hydrate (Ibu-Pro-QH). Ibu-Pro was prepared only by solid-state mechanochemical synthesis, while Ibu-Pro-QH obtained both solution-state crystallization mechanochemistry. The crystal structures were determined directly from powder X-ray diffr...

The proportions of axial anomers of various glucosylamines (2) and their conjugate acids were determined by 1H NMR. The change upon N-protonation is small and can be accounted for by steric effects, without any "reverse anomeric effect." To test whether N-protonation changes the steric bulk of an imidazolyl group, ring-inversion equilibria of cis-N-(4-alkylcyclohexyl)imidazoles (3c, 4c) and of ...

We have synthesized and characterized a new class of heme-peptide complexes using disulfide-linked hairpin-turn and cyclic peptides and compared these to their linear analogues. The binding affinities, helicities, and mechanism of binding of linear, hairpin, and cyclic peptides to [FeIII(coproporphyrin-I)]+ have been determined. In a minimalist approach, we utilize amphiphilic peptide sequences...