Abstract Multiple morphological abnormalities of the sperm flagella (MMAF) is one major causes male infertility and characterized by multiple defects. In this study, we found that coiled-coil domain-containing 189 (Ccdc189) gene was predominantly expressed in mouse testes inactivation Ccdc189 caused infertility. Histological studies revealed most from Ccdc189-deficient mice carried coiled, curv...

Electron Microscopy is an indispensable tool to investigate the intricate structures of the cell and organelles, and also to study the cellular biological processes implicated in the responses to changes in the microenvironment. However, several cellular events may be missed if conventional ultrastructural studies are not complemented with details concerning the subcellular localization of a wi...

NAD(P)H:quinone oxidoreductase 1 (NQO1) is implicated in both chemoprevention and bioactivation of DNA-damaging antitumor agents. NQO1 is mainly cytosolic, but distribution in other cellular compartments, particularly in tumor cells, is poorly defined. Nuclear NQO1 in HT29 human colon carcinoma and H661 human non-small cell lung cancer cells was observed using both confocal microscopy and immun...