silybum marianum, is known to have anti-inflammatory, hepatoprotective and anticarciogenic effects. the aim of this study was to compare effects of silymarin, rapamycin and fk506 on proliferation and apoptosis of human t cells stimulated with con a. peripheral blood mononuclear cells (pbmc) were stimulated with concavalin a  ( con a) (5µg/ml) and then treated with different inhibitors (silymari...

Allergic pathology of skin is one the most pressing problems modern pediatry. The common allergic dermatoses: simple and contact dermatitis, atopic various forms eczema, acute chronic urticaria, Quincke's edema, toxicodermias, multiforme exudative erythema (Stevens-Johnson syndrome), epidermal necrolysis (Lyell's syndrome). Many aspects systemic treatment dermatoses in children are complex cont...

PurposeTo investigate the efficacy of biosimilar infliximab compared to that originator for treatment chronic non-infectious uveitis.DesignBefore-and-after study.MethodsAll patients in Central Norway Health Region between 2007 and 2018 were included. They switched from therapy 2014 2017. The primary outcome was quiescence uveitis before after switch. All seen every 1-3 months. Visits binned int...

background: the expanse of dendritic cells (dc) differentiation plays an important role in determining immune response. dc-based immunosuppressive drugs have notable side effects in increasing the risk of infectious diseases and cancers. g2013, as a novel anti-inflammatory and immunosuppressive agent, has been tested in experimental model of multiple sclerosis. the aim of this study was to cond...

Corticosteroids have been the mainstay of uveitis therapy. When intraocular inflammation is unresponsive to steroids, or steroid related side effects become a concern, steroid-sparing medications may be administered which can be classified into immunosuppressive and immunomodulatory agents. Uveitis treatment can be delivered systemically, topically, periocularly or intraocularly. All of the abo...

INTRODUCTION Lifestyle after transplantation is the key link between transplantation and its outcome, and it is crucial to comply with the recommended life style behaviors. Our aim was to assess the compliance of kidney transplant recipients to the recommended life style behaviors in Mansoura, Egypt. MATERIALS AND METHODS One hundred kidney transplant patients were surveyed on their complianc...

balb/c mice are highly susceptible to infection with the protozoan parasite leishmania major. this susceptibility has been attributed in part to the expansion of th2 cells and production of their cytokines, il-4 and il-10 and down-regulation of th1 cytokine, inf-γ. the inability of susceptible hosts to mount the immune response necessary to activate macrophage and destroy the parasites can be d...

pemphigus vulgaris (pv) is one of the most common and studied autoimmune disorders of skin. the knock down of desmogleins in the skin by igg antibodies will eventually leads to mucocutaneous problems in both genders. targeting the cardinal molecules involved in the pathways of immune response is the main goal of given therapy. with regard to the side effects of long term use of immunosuppressiv...

BACKGROUND After the introduction of novel effective immunosuppressive therapies, kidney transplantation became the treatment of choice for end stage renal disease. While these new therapies lead to better graft survival, they can also cause a variety of complications. Only small series or case reports describe pulmonary pathology in renal allograft recipients on mTOR inhibitor inclusive therap...