AIMS Rising rates of obesity have led to an increasing prevalence of Type 2 diabetes mellitus in young people. Uncertainty exists over the utility of screening younger adults for Type 2 diabetes, as existing data sets have focused on mature (> 40 years) cohorts. The aim of this study was to determine the prevalence of impaired glucose metabolism in higher risk younger adults. METHODS Overweig...

Using the hyperglycemic and euglycemic clamp, we demonstrated impaired b-cell function in obese youth with increasing dysglycemia. Herein we describe oral glucose tolerance test (OGTT)–modeled b-cell function and incretin effect in obese adolescents spanning the range of glucose tolerance. b-Cell function parameters were derived from established mathematical models yielding b-cell glucose sensi...

BACKGROUND Recent epidemiological and experimental data suggest a negative influence of shortened or disturbed night sleep on glucose tolerance. Due to the high prevalence of sleep disorders this might be a major health issue. However, no comparative studies of carbohydrate metabolism have been conducted in clinical sleep disorders. METHODOLOGY/PRINCIPAL FINDINGS We performed oral glucose tol...

Resistin is a 12.5-kDa cysteine-rich protein secreted from adipose tissue and is an important factor linking obesity with insulin resistance. Here, we investigated the effect of resistin on glucose tolerance in adult human hepatocytes (L-02 cells). In this study, resistin cDNA was transfected into L-02 cells, and glucose concentration and glucokinase activity were determined subsequently. The d...

RESEARCH DESIGN AND METHODS — The Reykjavı́k Study, a population-based cohort study during 1967–1997, recruited 19,381 participants aged 33–84 years who were followed until 2002. Oral glucose tolerance tests and chest X-rays were obtained from all participants. Cases were defined in accordance with World Health Organization criteria for type 2 diabetes or AGR (impaired glucose tolerance or impai...

introduction: the aim of this study was to determine the prevalences of diagnosed and undiagnosed diabetes mellitus, impaired fasting glucose (ifg), impaired glucose tolerance (igt), and combined ifg/igt and to develop an effective screening strategy for undiagnosed diabetes in a large urban iranian community. materials and methods: the study population included 9,519 participants of the tehran...

Of 30 patients with chronic liver disease 16 showed some degree of impairment of glucose tolerance, and 16 patients had lack of suppression of raised fasting growth hormone levels or showed an anomalous rise after oral glucose. No relationship, however, existed between the state of glucose tolerance and the presence of abnormal growth hormone levels. Plasma glucose in those with normal growth h...

Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) represent intermediate states between normal fasting glucose (NFG) or normal glucose tolerance (NGT), respectively, and diabetes (1). The regulation of fasting and glucose concentrations after an oral glucose load is dependent on different physiological mechanisms (2), and current evidence suggests that IFG and IGT have differe...

Before having received any insulin, the serum insulin level was abnormally low in relation to the blood glucose level (Table). At the time of diagnosis some degree of insensitivity to insulin was suggested since injection of 2 units crystalline insulin intravenously (1 0 unit/kg) caused a less than 50% decrease in blood sugar concentration after 30 minutes. The necessity for insulin treatment f...