Aminopeptidases in the endoplasmic reticulum (ER) can cleave antigenic peptides and in so doing either create or destroy MHC class I-presented epitopes. However, the specificity of this trimming process overall and of the major ER aminopeptidase ERAP1 in particular is not well understood. This issue is important because peptide trimming influences the magnitude and specificity of CD8 T cell res...

This paper describes a new program simplification technique called program trimming that aims to improve the scalability and precision of safety checking tools. Given a program P, program trimming generates a new program P ′ such that P and P ′ are equi-safe (i.e., P ′ has a bug if and only if P has a bug), but P ′ has fewer execution paths than P. Since many program analyzers are sensitive to ...

To gain insight into how sugar chain processing events modulate endoplasmic reticulum (ER)/proteasomal degradation we looked at human asialoglycoprotein receptor polypeptides H2a and H2b, variants which differ only by an extra pentapeptide (EGHRG) present in H2a. Membrane-bound H2a is a precursor of a soluble secreted form while H2b reaches the plasma membrane. Uncleaved precursor H2a molecules...

Semantic caching is a dynamic caching strategy which deals with not only exact but also inexact similar queries, as the local cache has the capability of analyzing the incoming queries. Therefore, in this manner, each query will be carefully analyzed by the cache manager to identify the part that can be retrieved from cache from the part that needs to be retrieved from the server. This trimming...

We carried out lacerations of 50%, followed by trimming, in ten turkey flexor tendons in vitro and measured the coefficient of friction at the tendon-pulley interface with loads of 200 g and 400 g and in 10 degrees , 30 degrees, 50 degrees and 70 degrees of flexion. Laceration increased the coefficient of friction from 0.12 for the intact tendon to 0.3 at both the test loads. Trimming the lacer...

Cavitation is one of the most well-known process faults that may occur in different industrial equipment especially centrifugal pumps. Cavitation also may happen in water pumps and turbines. Sometimes cavitation has been severe enough to wear holes in the impeller and damage the vanes to such a degree that the impeller becomes very ineffective. More commonly, the pump efficiency will decrease s...

In this paper A Geometrical Design Method for Blade’s surface I in the impeller is provided here I is a solution to a coupling system consisting of the well-known Navier-Stokes equations and a four order elliptic boundary value problem . The coupling system is used to describe the relations between solutions of Navier-Stokes equations and the geometry of the domain occupied by fluids, and also ...

To explore the influence of tip clearance on pressure fluctuation in a low specific speed mixed-flow pump, tip clearances δ of 0.25 mm, 0.75 mm and 1.00 mm, along with no tip clearance, were selected. The reliability of the simulation was verified by comparison with the experimental data of external characteristics and fluctuation in the guide vane passage. Through ANSYS-CFX, MATLAB code and fa...

among the major stressors in poultry that cause suffering and death of chickens. Beak trimming, removal of 1/3 to 1/2 of the beak, is a routine husbandry procedure practiced in the poultry industry, including laying hens, broiler breeders, turkey and ducks, to prevent those undesirable behaviors. However, beak trimming is a painful procedure. There is a considerable body of morphological, neuro...

We demonstrated a vertically coupled microring resonator (VCMRR) filter as an Add/Drop wavelength filter. However, the accuracy of center wavelength was not sufficiently high for dense wavelength division multiplexing (DWDM) systems. Thus, a UV trimming technique using a SiN (n=2.01 at λ=1.55 μm) ring core was previously developed. Although a wide center wavelength trimming range of −12.1 nm an...