An orphan medicinal product, eculizumab is approved in Japan and globally for treating paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Eculizumab therapy can cause late complement pathway deficiencies that predispose patients to meningococcal infections. Although meningococcal vaccinations are typically considered mandatory for eculizumab therapy, no approved vaccine...

Abstract: Growing global international travel has reflected significantly on the number of imported cases malaria into non endemic regions world inclusive Saudi Arabia were transmission disease is controlled. This success in control could be challenged by influx disease. research looks at genetic diversity merozoite proteins 1 and 2 (msp msp 2) Plasmodium falciparum gene cases. Blood samples co...

INTRODUCTION Although there have been several phylogenetic studies on Plasmodium knowlesi (P. knowlesi), only cytochrome c oxidase subunit 1 (COX1) gene analysis has shown some geographical differentiation between the isolates of different countries. METHODS Phylogenetic analysis of locally acquired P. knowlesi infections, based on circumsporozoite, small subunit ribosomal ribonucleic acid (S...

BACKGROUND Understanding geographic and temporal trends in imported infections is key to the management of unwell travellers. Many tropical infections can be managed as outpatients, with admission reserved for severe cases. METHODS We prospectively recorded the diagnosis and travel history of patients admitted between 2000 and 2015. We describe the common tropical and non-tropical infectious ...

For 20 years after the end of World War II, infectious diseases were endemic throughout Japan, which served during this first postwar phase almost as a museum of communicable diseases. Improvements in socioeconomic conditions , infrastructure (especially water and sewerage systems), and nutrition brought about a rapid reduction in rates of acute enteric bacterial and parasitic infections. The d...

Zika is a re-emerging, mosquito-borne viral infection, which has been recently shown to cause microcephaly and Guillain-Barré syndrome. Since 2015 the number of infected patients has increased significantly in South America. The purpose of this study was to identify the epidemiologic and clinical characteristics of patients with Zika virus (ZIKV) infections in Korea. Patients who had visited ar...

Background: Bloodstream Infections (BSIs) that arise secondary to urinary tract infections (UTIs) are frequently encountered in both community and hospital settings associated with significant morbidity, mortality, high healthcare costs prolonged stays Objective: This descriptive review aims evaluate available information on the relationship of healthcare-associated community-onset bloodstream ...

Background. The variety and number of imported exotic infections acquired by Midwest travelers and immigrants is not well known. Midwest physicians, particularly in rural settings, may not consider a foreign exotic infection as the cause of illness among patients who were also travelers or immigrants. We reviewed our past experience in patients diagnosed with a foreign exotic infection at the U...

From January to April 2012, 16 cases of W135 invasive meningococcal infection were reported in France. Of these, eight were linked to a recent travel history to Sub-Saharan Africa. These cases were reported in France concomitantly with the meningitis epidemic season in Sub-Saharan Africa. Considering the high number of travellers between France and West-African countries belonging to the so-cal...