The pathogenesis and nosology of HIV-associated neurological disease (HAND) remain incompletely understood. Here, to provide new insight into the molecular events leading to neurocognitive impairments (NCI) in HIV infection, we analyzed pathway dysregulations in gene expression profiles of HIV-infected patients with or without NCI and HIV encephalitis (HIVE) and control subjects. The Gene Set E...

A hallmark of persistent HIV-1 infection in the central nervous system is increased activation of mononuclear phagocytes and surrounding astrogliosis, conferring persistent HIV-induced inflammation. This inflammation is believed to result in neuronal dysfunction and the clinical manifestations of HIV-associated neurocognitive disorders (HAND). The Jak/STAT pathway is activated in macrophages/my...

BACKGROUND In the honey bee, the age-related and socially regulated transition of workers from in-hive task performance (e.g., caring for young) to foraging (provisioning the hive) is associated with changes in many behaviors including the 24-hour pattern of rhythmic activity. We have previously shown that the hive-bee to forager transition is associated with extensive changes in brain gene exp...

BACKGROUND Monocyte/macrophages are known to infiltrate the brain of patients with HIV-1 encephalitis (HIVE). In Alzheimer's disease brain, the origin of activated microglia has not been determined. MATERIALS AND METHODS We employed the antigen retrieval technique, immunocytochemistry, immunofluorescense, and confocal microscopy to identify macrophages and microglia in relation to amyloid-bet...

In this paper we present HIVE (2016), a parametrically designed interactive sound sculpture with embedded multichannel digital audio which explores the intersection of sculptural form and musical instrument design. We examine sculpture as an integral part of music composition and performance, expanding the definition of musical instrument to include the gestalt of loudspeakers, architectural sp...

Mask of the Hive, a virtual embodiment of a simulated bee colony, an inherently decentralized interactive character, built under the Synthetic Characters behavioral framework.

This Special Issue of Digital Culture and Education (DCE), Building the HIVe, offers relevant and applicable examples of digital technologies being leveraged, positioned and practiced towards communitybased and led HIV prevention as a solution in a digital era. The contributors to this Special Issue, frontline workers, activists, researchers and educators alike, have taken risks as they have ex...