Objectives: We evaluated efficacy and safety of istradefylline that is the first selective adenosineA2A receptor antagonist, for the treatment of non-motor symptoms and quality of life (QoL) inParkinson’s disease (PD) patients with and QoL in their caregivers. Methods: This was a multi-sites study of 40 PD patients (female 24, male 16) who fully filled UK PD society brain bank clini...

Bourgain’s discretization theorem asserts that there exists a universal constant C ∈ (0,∞) with the following property. Let X,Y be Banach spaces with dimX = n. Fix D ∈ (1,∞) and set δ = e−nCn . Assume that N is a δ-net in the unit ball of X and that N admits a bi-Lipschitz embedding into Y with distortion at most D. Then the entire space X admits a bi-Lipschitz embedding into Y with distortion ...

To optimize the mechanical properties for biodegradable orthopedic implant, microstructures and tensile properties of Mg-Zn-Y alloys containing long period stacking ordered (LPSO) phase were investigated. For the as-cast Mg(100-3x)(Zn(1)Y(2))(x) (1 ≤ x ≤ 3) alloys, volume fraction of 18R LPSO phase increases with increasing the contents of Zn and Y. Mg(97)Zn(1)Y(2) alloy exhibits the optimal co...

PCTAIRE-1 (cyclin-dependent kinase [CDK] 16) is a highly conserved serine/threonine kinase that belongs to the CDK family of protein kinases. Little is known regarding PCTAIRE-1 regulation and function and no robust assay exists to assess PCTAIRE-1 activity mainly due to a lack of information regarding its preferred consensus motif and the lack of bona fide substrates. We used positional scanni...

BACKGROUND Chinese medicine comprised of all natural herbs is widespread used in the treatment of diabetic nephropathy (DN). Podocyte contributes to the integrity of glomerular filtration barrier whose injury plays an important role in the initiation and progression of DN. Our study aimed to investigate the effect of Qiwei granules on podocyte lesion in diabetic KK-A(y) mice kidney and its unde...

Vascular relaxation via endothelium-derived hyperpolarizing factor (EDHF) declines in association with aging and also with hypertension, and antihypertensive treatment improves the endothelial dysfunction connected with hypertension. We tested whether the angiotensin-converting enzyme inhibitor improves EDHF-mediated responses in normotensive rats, with special reference to the age-related proc...

We study the thermal behaviour of a tri-layer multilayer, designed by inserting a third material, yttrium, into the previously studied Co/Mo2C system. The system is designed to work at near-normal incidence at the wavelength of 14.1 nm. The theoretical reflectivity of Co-based multilayer (Co/Mo2C/Y system) is improved up to 54% after the addition of yttrium. Two types of multilayers with differ...

In this paper, we use the structure theory to prove an analog to a well-known theorem of Herstein as follows: Let R be a ring with center C such that for all x,y ? R either [x,y]= 0 or x-x [x,y]? C for some non negative integer n= n(x,y) dependingon x and y. Then R is commutative.

Consider y" (t) + A (t)y (t) + 0, y is a real n-dimensinal vector and A(t) is a real nxn matrix, continuous on some interval. Some positivity properties of solutions and conjugate points of y"(t) + A(t)y (t) = 0 appeared in literature. We prove similar results for focal points