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Sarcoidosis is a multisystem noncaseating granulomatous disease with a propensity for lung, eye, and skin which recently have been proposed that mycobacterium tuberculosis may contribute in its pathogenesis, and rarely involves central nervous system (CNS). Despite CD4+ lymphocytopenia, sarcoidosis by itself does not increase risk of opportunistic infections other than cryptococcosis.Nonethel...
The use of pharmacological agents in intensive care units (ICUs) is ever on the increase, with novel therapies appearing in the literature regularly. The complexities of polypharmacy are a challenge to the intensivist, and any guidance as to which drugs to use, when to use them and how much to use is always welcome. Happily, therefore, over the past 2 months a number of interesting papers and a...
The genomes of the nematodes Caenorhabditis elegans and Caenorhabditis briggsae both contain approximately 100,000 introns, of which >6,000 are unique to one or the other species. To study the origins of new introns, we used a conservative method involving phylogenetic comparisons to animal orthologs and nematode paralogs to identify cases where an intron content difference between C. elegans a...
Introduction: Based on reviewing several large reports in literature, less than 3 percent of glioblastoma occurred in the first two decades of life. In the Asian reports glioblastoma is more common than western reports. As there was no similar report in Iran; this study was designed for evaluating the presence of glioblastoma cases in first two decades of life. Methods: In this cross-sectional...
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