uence the outcome of IA are drug pharmacokinetics, site of infection, host factors, and the infecting fungus characteristics, including its susceptibility to the drug. In this setting, in vitro antifungal minimal inhibitory concentration (MIC) determination cannot reliably predict in vivo clinical outcome in a patient. In practice, while it may not always be possible to identify which patients ...

OBJECTIVE In vitro susceptibility results of 29 clinical isolates of Rhodotorula spp. were analysed. In addition, the susceptibility profile of another 102 Rhodotorula isolates was reviewed. METHODS The review included studies using antifungal susceptibility testing reference procedures or commercial methods exhibiting high correlation rates with reference procedures (Etest and Sensititre Yea...

Purpose: To evaluate the profile of in vitro susceptibility of yeasts isolated from cases of primary and espisodic vulvovaginitis to two antifungal agents. Methods: 40 Candida isolates from episodes of vulvovaginal candidiasis were identified by classic methodologies. The susceptibility testing of the in vitro fluconazole and ketoconazole activity against the isolates was accessed by E-test. Re...

OBJECTIVES There is scarce information on the clinical relevance and antifungal susceptibility of Candida bracarensis, Candida nivariensis, Candida orthopsilosis and Candida metapsilosis. The objective of this study was to assess the prevalence and in vitro antifungal susceptibility of these cryptic species among 173 blood isolates previously identified as Candida glabrata or Candida parapsilos...

Coelomycetes are being recovered with increasing frequency in human disease. They are frequently acquired by traumatic implantation and are of concern in profoundly immunosuppressed individuals. A definition of this group of organisms is provided, along with their clinical manifestations, methods for laboratory diagnosis, criteria for identification, in vitro susceptibility data, and guidelines...

Molecular identification and in vitro antifungal susceptibility tests of 43 Aspergillus section Nigri isolates from China were performed. Aspergillus niger and Aspergillus tubingensis were present in almost equal numbers. All of the isolates had low MIC/MECs (minimum effective concentrations) for the 7 common antifungals, and a paradoxical effect was observed for the first time in response to c...

Antifungal resistance has been associated with biofilm formation in many microorganisms, but not yet in Malassezia pachydermatis. This saprophytic yeast can cause otitis and dermatitis in dogs and has emerged as an important human pathogen, responsible for systemic infections in neonates in intensive care units. This study aims to evaluate the in vitro antifungal susceptibility of M. pachyderma...

The antifungal susceptibility results for 32 clinical isolates of Scopulariopsis brevicaulis are presented. Flucytosine and itraconazole were inactive in vitro, and MICs of amphotericin B, voriconazole, and terbinafine for all isolates were high, with geometric means of 13, 25.8, and 14.4 microg/ml, respectively.

Methods for the susceptibility test of yeast to antifungal agents have been standardized by the National Committee for Clinical Laboratory Standards7), while the standard method has not yet been established for the filamentous fungi. Furthermore, the in vitro activity of azole antifungal agents is known to be affected by various assay conditions8^12). For these reasons, measuring the in vivo ac...