results the results obtained for each drug were compared with other drugs and also with the results of the control groups. the results related to promastigote and amastigote assays showed that when the dose of both drugs increased, the parasite number is reduced in comparison with the control groups. moreover, the parasitic burden in the test cultures decreased significantly. macrophage assay r...

objective: to evaluate the efficacy of in vitro sperm activation (isa) using non-liquefied versus liquefied asthenozoospermic semen samples for improvement of sperm parameters. materials and methods: fifty six oligoasthenozoospermic (oa) patients (age range: 22-44 years; mean: 32.089 years) were enrolled in this study. oa patients were classified according to type of infertility. also, duration...

traumatic brain injury (tbi) is caused by rapid deformation of the brain, resulting in a cascade of pathological events and ultimately neurodegeneration. in vitro models of tbi can help us to describe the pathobiological mechanisms. in vitro models of brain injury support a platform for performing repeatable, well-controlled, environmentally isolated experiments. other advantages of in vitro mo...

Higher plants are a potential source of new drugs to improve the treatment of Chagase disease, which is affecting 16-18 million people, with more than 100 million exposed to the risk of infection (Ambrozin et al., 2004; Coura & Castro, 2002). Current therapy is unsatisfactory, because the only two drugs available, benznidazole and nifortimox possess severe side effects and their activity is lim...

Achillea moschata Wulfen (Asteraceae) is an endemic species growing on the Alps and traditionally used in several medicinal remedies. For its aromatic properties, it is also collected for food purposes. Chemical content and biological activity of A. moschata oil are not extensively studied. We investigated whether the different lithological and geomorphological features of two alpine areas incl...

Background Male infertility management has made significant progress during the past three decades, especially after the introduction of intracytoplasmic sperm injection (ICSI) in 1992. However, many boys and men still suffer from primary testicular failure due to acquired or genetic causes. New and novel treatments are needed to address these issues. Spermatogenesis originates from spermatogon...

phlomis lanceolata is a medicinal plant that has long been used to treat various conditions such as diabetes, gastric ulcer, hemorrhoids, inflammation and wounds. as most of phlomis species have shown cytotoxic activity against proliferation of different cell lines, a biological investigation of p. lanceolata was carried out in this study. the aim of this study was to find out the in vitro cyto...