To compare the myocardial uptake pattern of 99mTc-labeled methoxyisobutyl isonitrile [( 99mTc] MIBI) and 201TI, planar scintigraphy were performed in both patients with documented coronary artery disease and subjects with a low likelihood of disease. Quantitative analysis was employed using a standard interpolative background subtraction algorithm and a new algorithm modified to better accommod...

UNLABELLED The constant-volume urinary bladder model in the standard MIRD Pamphlet No. 5 (Revised) phantom has recognized limitations. Various investigators have developed detailed models incorporating more physiologically realistic features, such as expanding bladder contents and residual volume, and variable urinary input rate, initial volume and first void time. We have reviewed these publis...

introduction: this study was launched to evaluate the sensitivity and specificity of 99mtc-ciprofloxacin to distinguish infection foci induced by staphylococcus aureus and inflammation lesions induced by carrageenan in the rat foot in comparison with 67ga-citrate scintigraphy. methods: the labeling and quality control of 99mtc-ciprofloxacin kits have been performed according to the manufacture...

UNLABELLED This study was designed to compare the tracer kinetics between 99mTc-sestamibi and 99mTc-tetrofosmin in a heterogeneous group of 24 patients admitted for routine perfusion imaging. METHODS Twelve patients were studied with 99mTc-tetrofosmin and 12 with 99mTc-sestamibi. In each group, six patients had a low likelihood for coronary artery disease, and six patients had angiographicall...

The present study was conducted to evaluate radioimmunoimaging (RII) and in vivo distribution of mixed antibodies 99mTc-EGFR-mAb and 99mTc-CD44- mAb in nude mice bearing human lung adenocarcinoma xenografts. Single and mixed applications of the two radiolabeled monoclonal antibodies (mAbs) were compared. Direct labeling of 99mTc was applied to radiolabel the EGFR and CD44 mAbs. The properties o...

The present case demonstrates a diffuse intense hepatic and, to a lesser degree, spleen, Tc-99m MDP uptake on a routine bone scintigraphy resembling liver-spleen imaging. A 49-year-old female with a history of anaplastic plasma cell tumor and suffering from bone pain was referred for bone scintigraphy to evaluate possible bone metastases. The bone scintigraphy showed diffuse hepatic and spleen ...

Introduction: 99mTc-MIBI has been proposed for use as an imaging agent for various tumors, including breast cancer, lung cancer, lymphomas, melanomas and brain neoplastic lesions. Brain tumors are very common and radiotherapy being major part of treatment following surgery. After radiotherapy, deteriorating clinical status can be due to either radiation necrosis or recurrent tumor. Comput...

Extrarenal uptake of 99mTc-DMSA is a rare finding, which has been described in some unusual conditions as bone metastasis, aortic aneurysm and hemangioma. The purpose of this report is to present two cases of abnormal 99mTc-DMSA uptake in the lungs, which remained unexplained even after radiologic assessment.

UNLABELLED SPECT using 99mTc-hexamethyl propyleneamine oxime (HMPAO) mainly reflects regional cerebral blood flow, however metabolic abnormalities also affect the retention of 99mTc-HMPAO. METHODS To rule out any flow factor, a test-tube model was used to evaluate the effects of metabolic alterations both on intracellular trapping of 99mTc-HMPAO and on extracellular glutamate and lactate dehy...

BACKGROUND Phosphatidylserine (PS) is a phospholipid normally located in the inner leaflet of the cell membrane. PS is translocated from the inner to the outer leaflet of the plasma membrane during the early stages of apoptosis and in necrosis. In cell and animal studies, reversible PS externalisation to the outer membrane leaflet has been observed in viable cells. Hence, PS markers have been p...