Objective: The NONO (non-POU domain-containing octamer-binding protein) is a multifunctional nuclear protein involved in RNA synthesis, transcriptional regulation, and DNA repair. However, the effect of on neointima induced by vascular injury or restenosis remains unclear. We hypothesized that required for maintaining integrity knockout may inhibit formation. Approach Results: gene KO (knockout...

objective: transplantation of mesenchymal stem cells (mscs) can promote functional recovery of the brain after hypoxic-ischemic brain damage (hibd). however, the mechanism regulating msc migration to a hypoxic-ischemic lesion is poorly understood. interaction between stromal cell-derived factor-1α (sdf-1α) and its cognate receptor cxc chemokine receptor 4 (cxcr4) is crucial for homing and migra...

Introduction:Among major trauma patients in the emergency department, leading cause of morbidity and mortality is a hemorrhagic shock. The low oxygen flow with hypovolemia believed to play significant role. Hence, supply essential severe massive hemorrhage. This study aimed investigate effect hypoxic condition variable treatments such as pentoxifylline (PTX), glycerol, hypertonic saline (HTS), ...

•A transwell assay can measure Treg control of effector T-cell migration•Treg enhanced migration toward CCL20 in psoriatic arthritis•Anti-TNF induced suppressed arthritis•Increased Th17:Treg ratio was reversed by anti-TNF arthritis Regulatory T cells (Treg) prevent the sites inflammation, thereby limiting disease progression. We investigated this aspect function using (PsA) as an exemplar chron...

Macrophages play a role in innate immune responses to various foreign antigens. Many products from primary tumors influence the activation and transmigration of macrophages. Here, we investigated a migration of macrophages stimulated with cancer cell culture-conditioned medium (CM). Macrophage activation by treatment with CM of B16F10 cells were judged by the increase in protein levels of induc...

Plant homeo domain finger protein 8 (PHF8), as an oncogene, has been highlighted in cancer development and progression. However, its clinical significance and underlying molecular mechanisms in colorectal cancer (CRC) remain to be fully elucidated. In the present study, the role of PHF8 in the progression of CRC was investigated. The mRNA and protein levels of PHF8 in tissues from patients with...

Breast and prostate cancer preferentially metastasize in the skeleton, inducing locally increased bone resorption by osteoclasts. Bisphosphonates (BPs), potent inhibitors of osteoclasts and bone resorption, are able to reduce metastatic bone lesions, but the metastasis-related cellular target molecules for BPs have not yet been identified. In osteoclasts, nitrogen-containing BPs inhibit the fun...

Proliferation and migration of vascular smooth muscle cells (VSMCs) are important events in the development of diabetic atherosclerosis. Previous studies have suggested that K(Ca)3.1 channels participate in atherosclerosis and coronary artery restenosis. In the present study, we attempted to clarify the roles of K(Ca)3.1 channels in the proliferation and migration of VSMCs using experimental ty...