Purpose To compare the efficacy of individualized herbal decoction with standard decoction for patients with stable bronchiectasis through N-of-1 trials. Methods We conducted a single center N-of-1 trials in 17 patients with stable bronchiectasis. Each N-of-1 trial contains three cycles. Each cycle is divided into two 4-week intervention including individualized decoction and fixed decoction ...

Alexandra Scholze, Ying Liu, Lise Pedersen, Shengqiang Xia, Heinz J. Roth, Berthold Hocher, Lars Melholt Rasmussen, and Martin Tepel Clinical Research Unit, Department of Nephrology, Odense University Hospital, Odense, Denmark; Institute of Clinical Research, University of Southern Denmark, Odense, Denmark; Institute of Molecular Medicine, Cardiovascular and Renal Research, University of Southe...

Drug treatment is in many cases ineffective. Besides patients who do not respond to the treatment can develop so called adverse drug reactions (ADRs) as a consequence of the treatment (cause over 100 000 deaths per year in USA). Pharmacogenetics is the discipline, which takes the patient’s genetic information of drug transporters, drug metabolising enzymes and drug receptors into account leadin...

Precision medicine research efforts both in basic science discovery and clinical implementation are well underway and promise to provide individualized preventions and treatments, improving overall health care delivery. To achieve these goals, advances in data capture and analysis are needed spanning different types of 'omic and clinical data. The efforts to enhance precise treatments for all m...

The efficient delivery of personalized medicine is a key goal of healthcare over the next decade. It is likely that PCR strategies will play an important role in the delivery of this goal. Digital PCR has certain advantages over more traditional PCR protocols. In this article we will discuss the current status of digital PCR, highlighting its advantages and focusing on how it can be utilized in...