BACKGROUND Tumour necrosis factor alpha (TNF-alpha) is involved in non-steroidal anti-inflammatory drug induced gastropathy. Nitric oxide (NO) is a mediator of gastrointestinal mucosal defence but, paradoxically, it also contributes to mucosal damage. AIMS We optimised the C57BL/6 mouse model of indomethacin induced gastropathy to evaluate the role of TNF-alpha and inducible nitric oxide synt...

The effects of NSAIDs (aspirin and indomethacin) on the isolated auricles of the rabbit heart were studied by observing the effects of these drugs on automaticity, excitability and contractility of the auricles. Aspirin (25,50,100 uM) produced concentration dependent depression in the automaticity of the SA node while indomethacin (10 uM, 25 uM) has stimulant effects and 50 uM produced depressa...

The role of prostaglandins in maintenance of resting cerebral blood flow (CBF) and in cerebral vaso­ dilatation during hypercapnia remains controversial. The effect of indomethacin, a cyclo-oxygenase inhibitor, on CBF and cerebrovascular resistance (CVR) was exam­ ined in conscious animals. Regional and total CBF were measured with radioactive microspheres, and the efficacy of blockade of prost...

The function and sites of action of prostaglandins (PGs) vary in different animal species and tissues. In this study the effects of PGs (E1, E2, F2 alpha ,D2) on intraocular muscles and outflow facility of the eye were investigated, using enucleated bovine eyes. None of these PGs exogenously applied influenced the neuromuscular transmission. By contrast, after treatment with indomethacin, all P...

BACKGROUND Tramadol is a centrally acting analgesic that is often used in conjunction with nonsteroidal anti-inflammatory drugs (NSAIDs). The effect of coadministration of tramadol and indomethacin on gastric barrier function in dogs is unknown. HYPOTHESIS/OBJECTIVES That coadministration of a nonselective NSAID (indomethacin) and tramadol would decrease recovery of barrier function as compar...

BACKGROUND AND PURPOSE Acemetacin is a non-steroidal anti-inflammatory drug which is rapidly bioconverted to indomethacin, but produces significantly less gastric damage than indomethacin. This study was performed to investigate several possible mechanisms that could account for the gastrointestinal tolerability of acemetacin. EXPERIMENTAL APPROACH The gastric and intestinal damaging effects ...

BACKGROUND This study evaluated the incidence of symptomatic radioulnar synostosis/heterotopic ossification after distal biceps tendon repair in patients receiving indomethacin prophylaxis. We hypothesized that indomethacin use postoperatively would decrease the occurrence of symptomatic synostosis. METHODS A single-center retrospective record review identified 124 patients undergoing distal ...

Prostaglandin E2 (PGE2) plays an important role in immunosuppression and tumor growth. PGE2 inhibitors such as aspirin and indomethacin suppress experimental tumor growth. Little is known of the relationship between PGE2 synthesis in brain tumors and the dose of aspirin or indomethacin. The present study was undertaken to evaluate the effect of different doses of aspirin and indomethacin on PGE...

BACKGROUND & OBJECTIVES Patent ductus arteriosus (PDA) is a frequent complication in premature infants. Intravenous indomethacin is the standard mode of medical therapy and has been shown to be efficacious in closing the ductus. In our setup, oral indomethacin is being regularly used for medical treatment of suspected or clinically diagnosed PDA. Non-availability of the parenteral preparation a...

Indomethacin, in combination with prochlorperazine and caffeine (IPC), is often overused by migraine patients who develop medication-overuse headache. Indomethacin clearance is slower in chronic migraine patients overusing IPC combination than in migraine patients only occasionally taking it. The objective of this study was to verify if indomethacin reduced clearance reverted to normal values a...