Oral administration of aqueous leaf extract of Cassia auriculata L. (100, 200, 400 and 600 mg/kg body wt daily for 21 days) to alloxan-induced mild diabetic (MD) and severe diabetic (SD) rabbits produced dose dependent fall in fasting blood glucose up to 400 mg/kg dose from day 3 to day 21. Further, a significant elevation in the levels of insulin and reduction in glycosylated haemoglobin (HbA1...

AIM This study assessed within 4 days of suppressive test in vivo antimalarial activity of Ethanolic extract of root and stem bark of Cassia sieberiana DC against chloroquine sensitive strain of Plasmodium berghei NK65 in mice. METHODOLOGY Two sets, each of five groups of four mice per each group were used. The groups of animals were administered with 100, 200, and 300 mg extract/kg body weig...

The present study was performed to identify the mechanism of action of hydroalcholic extract of Cassia fistula leaf in blood glucose lowering effect. The extract was tested for hypoglycemic, oral glucose tolerance and antidiabetic effect in two dose levels, 200 and 400 mg/kg, using glibenclamide (0.5 mg/kg) as standard. Other in vivo models included glucose uptake studies in psoas muscle, intes...

Cassia angustifolia Vahl (senna) is a natural product that contains sennosides, which are active components that affect the intestinal tract and induce diarrhea. Authors have shown that senna produces DNA (deoxyribonucleic acid) lesions in Escherichia coli cultures and can act as an antifungal agent. Natural drugs can alter the labeling of blood constituents with technetium-⁹⁹m (⁹⁹mTc) and can ...

BACKGROUND Natural products made from plant sources have been used in a variety of cosmetic applications as a source of nutrition and as a whitening agent. The flowers of Cassia fistula L, family Fabaceae, have been used as a traditional medicine for skin diseases and wound healing and have been reported to possess anti-oxidant properties. The anti-aging effect of C. fistula flower extract on h...

Typhoid fever continues to be a serious health problem in developing countries. In our search for therapeutic agents from natural sources with potential for the treatment of typhoid fevers, an anti-typhoid aqueous extract was obtained from the leaves of Cassia petersiana and tested for possible toxicity risks. Toxicological study was done in mice and rats using both acute and sub-chronic techni...

Plant extracts have a long history to be used in folk medicine. Cassia alata extracts are known to exert antibacterial activity but details on compounds and mechanism of action remain poorly explored. We purified and concentrated the aqueous leaf extract of C. alata by reverse phase-solid phase extraction and screened the resulting CaRP extract for antimicrobial activity. CaRP extract exhibited...

A water soluble galactomannan having D-Mannose [4-part] and D-Galactose [2-parts] was isolated from Cassia fistula. In cassia fistula Hydrolysis of methylated seed gum furnished three methylated sugars, 2, 3-di-O-methyl-D-mannose, 2, 3,6-tri-O-methyl-D-mannose and 2, 3,4,6-tetra-Omethy-D-galactose was present in molar ratio 3:2:1. Partial acid catalysed hydrolysis of the seed gum gave five olig...

For centuries, mulberry leaf has been used in traditional Chinese medicine for the treatment of diabetes. This study aims to test the prevention effects of a proprietary mulberry leaf extract (MLE) and a formula consisting of MLE, fenugreek seed extract, and cinnamon cassia extract (MLEF) on insulin resistance development in animals. MLE was refined to contain 5% 1-deoxynojirimycin by weight. M...

identified hyperglycemia as the main risk-factor for the development of complications. Persistent hyperglycemia induces abnormal changes such as the formation of advanced glycation end products (AGEs), the increase of sorbitol through the polyol pathway, the overactivation of protein kinase C isoforms due to the synthesis of diacylglycerol (DAG). Direct evidence indicating the contribution of A...