The effect of various toxic agents on granulocytes or their precursors is reviewed with emphasis on hypoplastic anemia, granylocytopenia (toxic, idiosyncratic and immune), leukemia and morphologic cytoplasmic and nuclear changes.

The neurological risks and benefits of atypical neuroleptics have received considerable attention in the medical literature, but there have been few controlled studies examining these risks in elderly patients. Well-designed, longterm prospective studies are needed to identify the safest and most effective treatment regimens for elderly patients, but until these studies are complete, clinicians...

36 INTRODUCTION Antipsychotic drugs are the mainstay of treatment of schizophrenia and other psychotic disorders. The therapeutic efficacy of these drugs is well established. However, these drugs are associated with a wide range of side effects, including a variety of movement disorders. The newer antipsychotics have a lower propensity to cause acute extrapyramidal side effects and tardive dysk...

Acute extrapyramidal syndromes (EPS), including dystonia, parkinsonism, and akathisia, are associated with the use of virtually all neuroleptic agents. They may be alleviated by reducing the neuroleptic dosage, switching to a lower-potency drug, or administering an adjunctive agent such as an anticholinergic, amantadine, benzodiazepine, or beta-blocker. Akathisia may be only partly dispelled by...

AIM Assessment of the specific clinical manifestations of hand-arm vibration syndrome (HAVS) or whole-body vibration syndrome (WBVS). PATIENTS AND METHODS Seventy-six patients (34 with HAVS and 33 with WBVS) were examined analysing the data from their medical history, clinical examinations and autonomic nervous system study, capillaroscopy, distal Doppler ultrasound study, vibrotactile sense,...

Movement disorders commonly are associated with many psychotropic drugs. Tricyclic antidepressants often cause a tremor in the hands and myoclonic jerks. In some patients, they result in agitation and restlessness, referred to as the jitteriness syndrome [1]. Occasional anecdotes of dyskinesia and dystonia have been reported with these drugs, but tardive dyskinesia typically is not associated w...

The aim of the study was to compare the lung sounds in patients with asbestos related pulmonary disorders with findings in high-resolution computed tomography (HRCT), and with lung function variables, in order to find out associations of acoustic changes with radiological fibrosis, emphysema or with pulmonary gas transfer functions. Sixty-four patients with asbestos-related pleural disease, wit...

J Dtsch Dermatol Ges 2006;4:308–18. In German. 19 Mahmud E, Brocato M, Palakodeti V, Tsimikas S. Fibromuscular dysplasia of renal arteries: percutaneous revascularization based on hemodynamic assessment with a pressure measurement guidewire. Catheter Cardiovasc Interv 2006;67:434–7. 20 Laforet P, Eymard B. [Exercise-intolerance and exercise-induced rhabdomyolysis: etiology and diagnosis.] Revie...

The determination of isocyanates concentrations in air is complicated by thepresence of these substances as monomers and oligomers as well as in thevapor and aerosol phases. Direct-reading instruments (DRIs) are available fordetermining the diisocyanate concentrations in workplace air, but they arecalibrated for the monomers only. Industry uses polymeric diisocyanateswhich c...