Abstract Background Recent basic studies demonstrate that the lung is a primary organ of platelet biogenesis. However, whether pathophysiological state affect platelets little known. We aim to investigate incidence thrombocytopenia in patients with pulmonary infection (PIN) and risk factors associated thrombocytopenia. Methods In total, 11,941 were enrolled, other three infectious diseases coll...

Drug-induced immune thrombocytopenia may be potentially fatal; here we report the development of severe thrombocytopenia with strong oxaliplatin-dependent antiplatelet antibodies.

The use of heparin have increased in the last years in hospitalized both as prophylaxis and therapeutic. One of the encounter complications of heparin especially with unfractionated heparin though it can be seen with Low molecular weight heparin is thrombocytopenia which could be transient non immune or more badly the immune mediated type heparin induced thrombocytopenia (HIT). Heparin-induced ...

Recently, reports of severe thromboses, thrombocytopenia, and hemorrhage in persons vaccinated with the chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19, AZD1222, Vaxzevria; Oxford/AstraZeneca) against acute respiratory syndrome coronavirus 2 have emerged. We describe an otherwise healthy 30-year-old woman who developed ecchymosis, portal vein thrombosis, cerebral venous sinus thrombosis...

Heparin-induced thrombocytopenia (HIT) is an immune-mediated clinical syndrome of thrombocytopenia and thrombosis occurring after exposure to heparin. HIT most commonly occurs after exposure to unfractionated heparin but has also been reported with low-molecular-weight heparin. To date, there have been very few reports of HIT with the pentasaccharide fondaparinux, and some have proposed fondapa...

Treatment of tuberculosis has many side effects. Thrombocytopenia is a serious side effect of such treatment and occurs mostly due to rifampicin (RIF). There are very few reported cases of thrombocytopenia due to isoniazid (INH). An 18-year-old female patient was diagnosed with smear-positive pulmonary tuberculosis. A four-drug regimen [INH, RIF, ethambutol (EMB), and pyrazinamide (PZA)] was gi...

BACKGROUND Delayed-onset heparin-induced thrombocytopenia with thrombosis, albeit rare, is a severe side effect of heparin exposure. It can occur within one month after coronary artery bypass grafting (CABG) with manifestation of different thrombotic events. CASE PRESENTATION A 59-year-old man presented with weakness, malaise, bilateral lower limb pitting edema and a suspected diagnosis of de...

Heparin-İnduced Thrombocytopenia (HIT) is a life-threatening complication that occurs in small percentage of exposed patients (e.g. unfractionated heparin, Low Molecular Weight Heparin [LMWH]) regardless dose and treatment management.

Previously we demonstrated that antibody-mediated thrombocytopenia is strongly enhanced by lactate dehydrogenase-elevating virus (LDV) infection. Here we report that mice infected with LDV develop a moderate thrombocytopenia, even in the absence of immunoglobulins or Fc receptors. A similar decrease of platelet counts was observed after mouse hepatitis virus infection. LDV-induced type I interf...

We represent here a 30-year-old woman with cardiac leiomyosarcoma who developed thrombocytopenia and deep vein thrombosis a few days after the start of low molecular weight heparin. Thrombocytopenia improved after replacement of low molecular weight heparin with hirudine. We speculated that cardiac leiomyosarcoma is a predisposing factor for development of heparin induced thrombocytopenia.