The development of resistance remains a major obstacle to long-term disease control in cancer patients treated with targeted therapies. In BRAF-mutant mouse models, we demonstrate that although targeted inhibition of either BRAF or VEGF initially suppresses the growth of BRAF-mutant tumors, combined inhibition of both pathways results in apoptosis, long-lasting tumor responses, reduction in lun...

Determining the mechanism of treatment failure of VEGF signaling inhibitors for malignant glioma patients would provide insight into approaches to overcome therapeutic resistance. In this study, we demonstrate that human glioblastoma tumors failing bevacizumab have an increase in the mean percentage of p-STAT3-expressing cells compared to samples taken from patients failing non-antiangiogenic t...

OBJECTIVE An inflammatory process is involved in the mechanism of obesity-related insulin resistance. Recent studies indicate that monocyte chemoattractant protein-1 (MCP-1) is a major chemokine that promotes monocyte infiltration into adipose tissues; however, the adhesion pathway in adipose tissues remains unclear. We aimed to clarify the adhesion molecules that mediate monocyte infiltration ...

infiltration in furrow irrigation is 2-d which depends on both time and surface characteristics at which infiltration occurs. however, in many furrow irrigation models, infiltration is determined as a function of infiltration time opportunity, assuming the variation of weted perimeter is low along furrow. in order to compare the proposed asumptions, two zero-inertia furrow irrigation models wer...

introduction: ventilator-associated pneumonia (vap) is one of the most common hospital infections and a side effect of lengthy stay in intensive care unit (icu). considering the ever-changing pattern of common pathogens in infectious diseases and the raise in prevalence of hospital infections, the present study was designed aiming to determine the prevalence of vap and its bacterial causes. met...

Thermal barrier coatings (TBCs) have been seriously threatened by calcium-magnesium-alumina-silicate (CMAS) corrosion. The search for novel ceramic TBCs with excellent resistance to CMAS corrosion is ongoing. Herein, behavior and the mechanism of a promising Hf6Ta2O17 coating are investigated. results show that temperature most important factor affecting mechanism. At 1250 °C, products composed...

introduction: the infiltration process is one of the most important components of the hydrologic cycle. quantifying the infiltration water into soil is of great importance in watershed management. prediction of flooding, erosion and pollutant transport all depends on the rate of runoff which is directly affected by the rate of infiltration. quantification of infiltration water into soil is also...

Diet-induced obesity causes chronic macrophage-driven inflammation in white adipose tissue (WAT) leading to insulin resistance. WAT macrophages, however, differ in their origin, gene expression and activities: unlike infiltrating monocyte-derived inflammatory macrophages, WAT-resident macrophages counteract inflammation and insulin resistance, yet, the mechanisms underlying their transcriptiona...

BACKGROUND: We report a case of a patient with apparent resistance to local anesthetics. While similar cases of failure of regional anesthetics are often attributed to technical failure, the overall clinical presentation and history of this patient suggests a true resistance to local anesthetics. CASE PRESENTATION: This patient presented for elective cesarean section and the decision for region...