This research proposes an agent-based simulation model combined with the strength of systemic dynamic mathematical model, providing a new modeling and simulation approach of the pathogenesis of AIR. AIR is the initial stage of a typical sepsis episode, often leading to severe sepsis or septic shocks. The process of AIR has been in the focal point affecting more than 750,000 patients annually in...

Arzanol is a novel phloroglucinol α -pyrone, isolated from a Mediterranean plant Helichrysum italicum (Roth) Don ssp. microphyllum which belongs to the family Asteraceae. Arzanol has been reported to possess a variety of pharmacological activities. However, anti-inflammatory, anti-HIV, and antioxidant activities have been studied in some detail. Arzanol has been reported to inhibit inflammatory...

In recent times, there has been growing interest in nanoparticles (NPs) synthesized through biological means due to their ease of production and potential applications the field biology. This study presents an environmentally friendly method for biogenic synthesis silver (AgNPs) using leaf extract Cymodocea serrulata as both a reducing agent capping agent. Various physico-chemical microscopic t...

Inflammation is a hallmark of many diseases. Although steroids and cyclooxygenase inhibitors are main anti-inflammatory therapeutical agents, they may cause serious side effects. Therefore, developing non-steroid anti-inflammatory agents is urgently needed. A novel hydrosoluble compound, C12 (2,6-bis(4-(3-(dimethylamino)-propoxy)benzylidene)cyclohexanone), has been designed and synthesized as a...

Carboxyamidotriazole (CAI) is a calcium influx inhibitor that is undergoing clinical trials for the treatment of various human cancers following the identification of its antiproliferative and antimetastatic activities. The exact mechanism of its action is not clearly understood, and whether it has other functions besides the established antitumor activity has not been reported either. In the p...

Curcumin, an active substance contained in Indian spice called turmeric or curcuma, is well known for its anti-inflammatory and antioxidant properties. In recent times, it was taken into account studied as antitumoral molecule, by relying on interference several biological mechanisms, such the inhibition of inflammatory mediators, enhancement detoxifying enzymes’ action processes cell growth pr...

Epidemiological studies suggest that acute kidney injury has certain effect on myocardial function. In this study, for the first time, we tested a boron compound namely lithium tetraborate an act as anti-oxidant and anti-inflammatory agent in ischemia-reperfusion injury. For this, employed vivo rat model with ischemia reperfusion to evaluate cardiac clarify mechanisms of tetraborate. The evalua...

in this paper, a formal model for antivirus update agent system is presented based on mobile agent technology and predicate/transition petri nets. the mobile agent system contains two mobile agents called dca and una. it sends out agents to update antivirus on client computers in a network. each agent takes on a specified responsibility. first, dca roams through the network and check the last d...