BACKGROUND Few studies address the dynamic effect of opioids on respiration. Models with intact feedback control of carbon dioxide on ventilation (non-steady-state models) that correctly incorporate the complex interaction among drug concentration, end-tidal partial pressure of carbon dioxide concentration, and ventilation yield reliable descriptions and predictions of the behavior of opioids. ...

The target-controlled infusion (TCI) technique has been successfully and commercially used in clinical general anaesthesia with the intravenous anaesthetic agent propofol. The technique is based on a population pharmacokinetic model and is an open-loop control system. Closed-loop control requires a reliable and consistent signal for feedback utilisation. With all anaesthetic agents the somatose...

INTRODUCTION Lactic acidosis is a frequent cause of poor outcome in the intensive care settings. We set up an experimental model of lactic acid infusion in normoxic and normotensive rats to investigate the systemic effects of lactic acidemia per se without the confounding factor of an underlying organic cause of acidosis. METHODOLOGY Sprague Dawley rats underwent a primed endovenous infusion ...

Banana has been widely cultivated. This study aimed to determine the antihyperglycemic activity of Uli banana leaves infusion. The was evaluated by oral glucose and sucrose tolerance test. A bolus sugar given after infusion blood sampled at 0, 15, 30, 60, 90 120 minutes for analyses. trapezoidal rule used area under curve (AUC) glucose. Infusion 3.3 g/kg showed a significant decrease AUC (p<...

TO THE EDITOR: Sorensen et al. (1) compare the production rate of triglyceride, as calculated from a bolus injection decay curve, to that obtained from a primed constant infusion curve of the specific activity of radiolabeled tracer. They note a difference in the two rates and choose the constant infusion as the more accurate method. But is it? The bi-exponential model is a predictive model and...

This paper presents a generic infusion pump user interface (GIP-UI) architecture that intends to capture the common characteristics and functionalities of interactive software incorporated in broad classes of infusion pumps. It is designed to facilitate the identification of use hazards and their causes in infusion pump designs. This architecture constitutes our first effort at establishing a m...

Abstract Background The unprecedented efficacy of chimeric antigen receptor T (CAR-T) cell immunotherapy CD19 + B-cell malignancies has opened a new and useful way for the treatment malignant tumors. Nonetheless, there are still formidable challenges in field CAR-T therapy, such as biodistribution cells vivo. Methods NALM-6, human acute lymphoblastic leukemia (B-ALL) line, was used target cells...

This paper presents a generic infusion pump user interface (GIP-UI) architecture that intends to capture the common characteristics and functionalities of interactive software incorporated in broad classes of infusion pumps. It is designed to facilitate the identification of use hazards and their causes in infusion pump designs. This architecture constitutes our first effort at establishing a m...