INTRODUCTION Computational fluid dynamics (CFD) has recently seen increased use in the design of pharmaceutical inhalers. The use of CFD in the design of inhalers is made difficult by the complex nature of aerosol generation. At present, CFD has provided valuable insight into certain aspects of inhaler performance, though limitations in computational power have prevented the full implementation...

BACKGROUND Poor adherence to inhaled medication may lead to inadequate symptom control in patients with respiratory disease. In practice it can be difficult to identify poor adherence. We designed an acoustic recording device, the INCA® (INhaler Compliance Assessment) device, which, when attached to an inhaler, identifies and records the time and technique of inhaler use, thereby providing obje...

Although most attention has been focused on the drugs used to control asthma, it is increasingly recognised that effective delivery of these drugs to the lungs is just as important. The most effective drugs, b2-agonists and corticosteroids, are given by inhalation so there has been a search for more efficient inhaler devices that are easier for patients to use. A symposium at the European Respi...

Delivery of drug aerosols to the lungs of ventilated neonates by metered dose inhaler and spacer (Aerochamber) and ultrasonic nebuliser (Pentasonic) was assessed using sodium cromoglycate. The mean proportion of a known intratracheal dose of sodium cromoglycate excreted in the urine of four intubated infants was 37.5%. After assuming that 38% of the sodium cromoglycate aerosol reaching the neon...

ABSTRACT: Preference for and satisfaction with inhaler devices may be associated with improved clinical outcomes, but this has not been proven to date. A screened Medline search for papers on preference for inhaler devices produced 29 studies on a variety of devices, with Advair Diskus1 and Turbuhaler featuring prominently. Of the 23 studies sponsored by the pharmaceutical industry, the sponsor...

Background It is a recurring theme in clinical practice that patients using inhaled medications via an inhaler do not use their device to standard allows for optimum therapeutic effect, and some studies have shown up 90% of people inhalers properly. Observation correction the technique by health care professionals advised both national international guidelines should be performed at every oppor...

BACKGROUND Medications for respiratory disorders including asthma and chronic obstructive pulmonary disease (COPD) are typically delivered to the lung by means of a handheld inhaler. Patient preference for and ability to use the inhaler may influence their adherence to maintenance therapy, and adherence may affect treatment outcomes. In this study, patient experience of using a dry powder inhal...

School nurses can have significant cohorts of students with asthma. Effectively managing asthma in school can be challenging in terms of time, resources, and outcomes. A valuable focus for the school nurse is inhaled medication administration. Understanding the details required for optimal inhalation technique with metered-dose inhalers is the foundation for developing the skills to deliver and...

BACKGROUND Previous studies have shown disparities between Black and Hispanic patients compared with other populations in response to asthma medications. OBJECTIVE The aim of this analysis was to assess the effect of budesonide/formoterol pressurized metered-dose inhaler (BUD/FM pMDI) and BUD on predefined criteria for asthma worsening, an asthma control metric generally aligned with definiti...

www.aafp.org/afp AMERICAN FAMILY PHYSICIAN 1341 possibility of adverse side effects or children have difficulty using metered-dose inhalers (MDIs). New therapeutic options are available and with aggressive, appropriate therapy, physicians can prescribe an asthma management regimen to ameliorate symptoms, control disease and allow normal activity even in children as young as one to two years.