objective(s):this study was carried out to investigate the effects of cox-2 selective inhibitor (celecoxib) or non-selective cox inhibitor (ibuprofen) on gastrointestinal motility. materials and methods: the rats were randomly divided into five groups including: intact, sham, traumatic brain injury (tbi) group (intact rats under tbi), celecoxib group (10 mg/kg), ibuprofen group (10 mg/kg). rats...

  Uncontrolled recurrent hemarthrosis can end to contracture, deformity, pain, joint destruction and gait disorders which are disabling. We are going to report a challenge, a unilateral knee flexion contracture in a child with severe hemophilia A and inhibitor who underwent different treatment options with unsatisfactory improvement of knee range of motion. Mismanaging postoperatively, patient ...

A quantum chemical study of the corrosion inhibition properties of some organic inhibitormolecules, pyridine, 2-picoline, 3-picoline, 4-picoline, 2, 4-lutidine at the aluminum surface inhydrochloric acid (HCl) was carried out. The models of the inhibitors adsorption on the Al-surfacewere optimized with the HF and B3LYP level using the 6-31G and LANL2DZ basis sets fromthe program package Gaussia...

Background: Leukemia inhibitor factor (LIF) is a very important pleiotropic cytokine which belongs to interleukin-6 (IL-6) family. LIF exerts multiple effects on different types of cells and tissues with numerous regulatory effects in vivo and in vitro. It is a lymphoid factor, which performs a number of activities including cholinergic neuron differentia‌tion, contro...

The Janus kinase inhibitor upadacitinib is a potential treatment for psoriatic arthritis. efficacy and safety of as compared with adalimumab, tumor necrosis factor α inhibitor, in patients who have an inadequate response to nonbiologic disease-modifying antirheumatic drugs are unclear.

This paper studies the corrosion inhibition of Al-Mg alloy system in 0.5 mol/dm3 NaCl solution in the presence of pyrazole derivative using potentiodynamic polarization and linear polarization method. The inhibition efficiency as a function of concentration and temperature was investigated. From the polarization curves, it can be concluded that the pyrazole derivative be...

Objective(s): Apelin/APJ system plays an important role in the regulation of myocardial contractility (MC) and blood pressure. Opioid receptors (OPRs) are also important cardiovascular regulators and exert many of their effects through modulating the function of other systems. This study analyzed the interaction between APJ and kappa OPRs (KOR) in cardiac responsiveness to apelin in acute reno-...

The aim of the current study is to evaluate the effects of inhibitors or solvents on asphaltene precipitation under reservoir conditions. To this end, the interaction between live oil and solvent, and its side effects on precipitated/dissolved asphaltene were predicted via Miller’s entropy modified polymer solution theory under reservoir conditions. Then, the adjustable parameters of the model ...

experimental acute gastric ulcer is produced by the intraperitoneal injection of a single dose of indomethacin. acetazoleamide, a potent carbonic anhydrase inhibitor, has significantly prevented the occurrence of these ulcers. its probable mechanism is discussed.