BACKGROUND In Sub-Saharan Africa, policy changes have begun to pave the way for community distribution of injectable contraceptives but sustaining such efforts remains challenging. Combining social marketing with community-based distribution provides an opportunity to recover some program costs and compensate workers with proceeds from contraceptive sales. This paper proposes a model for increa...

Light-Activated Injectable Fat Grafts The artwork highlights an injectable fat graft for soft tissue reconstruction. In article number 2300538, Khoon S Lim and co-workers develop apply a light-activated macromolecular chemistry to facilitate crosslinking of patient-derived lipoaspirate, resulting in better control over the shape fidelity mechanics grafts. This grafts are easily administered sit...

OBJECTIVE To assess the effects of prophylactic misoprostol use in the third stage of labor compared with injectable uterotonics or placebo or no treatment. DATA SOURCES The Cochrane Pregnancy and Childbirth Group trials register; the Cochrane Library, including databases such as the database of systematic reviews and the Cochrane Controlled Trials Register; and MEDLINE were searched. Researc...

BACKGROUND Long-acting injectable risperidone, a second-generation antipsychotic agent, may improve adherence to treatment and outcomes in schizophrenia, but it has not been tested in a long-term randomized trial involving patients with unstable disease. METHODS We randomly assigned patients in the Veterans Affairs (VA) system who had schizophrenia or schizoaffective disorder and who had been...

Cellulose nanocrystals (CNCs) have been widely studied as fillers to form reinforced nanocomposites with a wide range of applications, including the biomedical field. Here, we evaluated possibility combine them fibrinogen and obtain fibrin hydrogels improved mechanical stability potential cellular scaffolds. In diluted conditions at neutral pH, it was evidenced that could adsorb on CNCs in two-...

In the current research, preparation and characterization of a series new biocompatible injectable bone paste (IBP) nanocomposites, hydroxyapatite-gelatin (HA-Gel), hydroxyapatite-gelatin-alendronate (HA-Gel-Ald np) are reported. IBP HA-Gel np, were synthesized from mixing different ratios gelatin to aqueous solutions both Ca(NO3)2.4H2O (NH4)2HPO4, while target HA-Gel-Ald obtained by submitting...

BACKGROUND Local anesthetics are an important component of perioperative pain management, but the duration of action of available products is limited. We hypothesized that a single local infiltration of a novel bupivacaine liposome injectable suspension (AT-003) would provide clinically effective analgesia over a 72-h period. In a masked, randomized, placebo-controlled, multi-center pilot field...

AIMS To compare the glycaemic outcomes of 2 glucose-lowering treatment strategies in vulnerable (moderately ill and/or frail) patients aged ≥65 years with type 2 diabetes whose individual HbA1c targets were not met with diet/exercise and/or oral anti-hyperglycaemic medications (OAMs). METHODS The primary endpoint of this study was a composite of achieving/maintaining individualized HbA1c targ...