Objective(s):The relationship between tramadol, as an antinociceptive drug, and locus coeruleus (LC), the main noradrenergic nucleus of the brain that affects regulation and modulation of pain through descending noradrenergic pathways was investigated. Materials and Methods: Male Sprague-Dawley rats were divided into four groups of 10 rats. The rats were fixed in stereotaxic instrument and then...

BACKGROUND Lidocaine has been used widely to prevent propofol injection pain. Various methods of administration exist, such as lidocaine premixed with propofol or lidocaine pretreatment using a tourniquet, but it is unclear which method of lidocaine administration is more effective for the prevention of injection pain of propofol LCT/MCT. The purpose of this study was to compare pretreatment of...

The emulsion formulation of propofol (Diprivan) evokes pain on i.v. injection, although its pH and osmolality are close to those of blood. The pain induced by serial dilutions of propofol in Intralipid and 5% glucose was examined in isolated vein segments and after intracutaneous injection. Propofol evoked pain in a concentration-related manner in six of eight subjects after i.v. perfusion and ...

We studied the effect of fentanyl pretreatment on alleviating pain during the injection of Propofol-Lipuro. One hundred and seventy patients were randomly allocated to receive either 100 mcg of intravenous fentanyl or normal saline (placebo) followed by intravenous Propofol-Lipuro premixed with 20 mg lignocaine. The incidence of injection pain was 32% and 13% in the placebo and fentanyl groups,...

OBJECTIVES: The purpose of the current study was to evaluate the effectiveness of vapocoolant for preschoolers’ immunization injection pain relief. STUDY DESIGN: 57 4to 6-year-old children were randomized to vapocoolant alone or typical care conditions. Pain was measured at baseline and at injection via self-report, caregiver-report, nurse-report, and an observational scale. RESULTS: Self-repor...

BACKGROUND Subacromial impingement is a common cause of shoulder complaints in general practice. When the initial treatment with acetaminophen and low dose Non Steroidal Anti Inflammatory Drugs fails, triamcinolone acetonide injections are commonly used. Triamcinolone acetonide injections are effective at four to six weeks. Little is known about the pain relief effect of triamcinolone acetonide...

Formalin as a chemical noxious stimulus evokes a biphasic pain that its second phase as a chronic inflammatory pain is similar to clinical pain. In this study, we used 40 NMRI male rats (250-300 g), and experiments were carried out considering ethical rules. Experiments were performed in normal and morphine addicted rats, the addiction was induced by Leung method. Behaviors of flinching and lic...