In adult mammals, injured axons regrow over long distances in peripheral nerves but fail to do so in the central nervous system. Analysis of molecular components of tissue environments that allow axonal regrowth revealed a dramatic increase in the level of hemopexin, a heme-transporting protein, in long-term axotomized peripheral nerve. In contrast, hemopexin did not accumulate in lesioned opti...

Axoplasmic proteins containing nuclear localization signals (NLS) signal retrogradely by an unknown mechanism in injured nerve. Here we demonstrate that the importin/karyopherin alpha and beta families underlie this process. We show that importins are found in axons at significant distances from the cell body and that importin beta protein is increased after nerve lesion by local translation of...

objective: to determine the effects of local administration of platelet rich plasma (prp) on peripheral nerve regeneration in rat sciatic nerve transection model. methods: forty-five male white wistar rats were randomized into three experimental groups (n = 15): normal control group (nc), silicon group (sil), prp treated group (sil/prp). in nc group left sciatic nerve was exposed through a glut...

Objective- The objective was to assess local effect of brain derived neurotrophic factor (BDNF) on functional recovery of peripheral nerve in rat sciatic nerve transection model. Design- Experimental study. Animals- Sixty male healthy white Wistar rats Procedures- The animalswere randomized into four experimental groups of 15 animals each: In sham-operated group (SHAM), sciatic nerve was exp...

gonadotropin-releasing hormone (gnrh) has neuromodulatory roles in central and peripheral nervous systems. the purpose of this study is to evaluate the effect of gnrh analog (buserelin) on peripheral nerve regeneration. forty adult male rats were divided into buserelin-treated, normal saline, sham surgery, and castrated + buserelin groups. the left sciatic nerve was crushed by a fine forceps an...

case presentation in this report, ultrasound-guided sciatic nerve block was performed in a 25-year-old patient with tetanus to progress his respiratory drive which was decreased due to high dose sedative administration. this procedure accelerates the weaning process and extubation. introduction muscle rigidity and generalized spasm can cause severe pain in patients with tetanus. administration ...

This study analyzed the effects of a low-level laser therapy (LLLT, 15 J/cm(2), 780 nm wavelength) and the natural latex protein (P1, 0.1%) in sciatic nerve after crush injury (15 Kgf, axonotmesis) in rats. Sixty rats (male, 250 g) were allocated into the 6 groups (n = 10): CG-control group; EG-nerve exposed; IG-injured nerve without treatment; LG-crushed nerve treated with LLLT; PG-injured ner...

despite promising results observed using silicone rubber chamber, no previous comprehensive work was performed on behavior of the conduit. present study aimed at further functional, histomorphometrical and immunohistochemical assessment of nerve regeneration in the same animal along a 10-mm rat sciatic nerve gap. fifty- four male wistar rats were divided into three experimental groups (n = 18),...