•CYRI-B structure reveals homology to CYFIP of the Scar/WAVE complex•CYRI-B shares a conserved interface with for Rac1 interaction•CYRI proteins form autoinhibited dimers that compete binding•Rac1-CYFIP model shows potential steric clashes RAC1 is major regulator actin dynamics, GTP-bound promoting assembly via complex. CYRI competes interaction in feedback loop regulating dynamics. Here, we re...

by regulating all of these activities. In particular, families of proline-rich proteins, the WASP/SCAR and Ena/VASP families, play crucial roles in actin dynamics, and are Song Hu and Louis F. Reichardt* Department of Physiology Howard Hughes Medical Institute University of California believed to act, at least in part, by binding and thereby regulating Profilin’s activity (Figure 1). In additio...

The popularity of unicompartmental knee arthroplasty (UKA) for the treatment of isolated compartment osteoarthritis of the knee has risen over the past 2 decades. Currently, UKA covers 10% of all knee arthroplasties worldwide. Although indications have been extended, results have proven that patient selection plays a critical role in the success of UKA. From the current perspective, age, body m...

after Mobile-bearing Total Knee Arthroplasty +Ishii, Y; Noguchi, H; Takeda, M; Sato, J +Ishii Orthopaedic & Rehabilitation Clinic, Gyoda, Saitama, JAPAN [email protected] INTRODUCTION: Postoperative studies using X-ray analyses have reported contradictory findings regarding whether PCO had an effect on flexion after total knee arthroplasty (TKA), since correctly recognizing which condyle ref...

An integral quadratic form is said to be strictly k-regular if it primitively represents all quadratic forms of k variables that are primitively represented by its genus. We show that, for $k \geq 2$, there are finitely many inequivalent positive definite primitive integral quadratic forms of k+4 variables that are strictly k-regular. Our result extends a recent finiteness result of Andrew Earn...

Among stress fractures associated with sports activities, patellar stress fracture is rare. Regarding patella stress fractures, so far only distal transverse or lateral longitudinal fractures have been reported, but there are no reports of transverse fractures occurring in the proximal patella. We describe an extremely rare case of transverse stress fracture of proximal patella in a 9-year-old ...

Durotaxis, the process by which cells follow gradients of extracellular mechanical stiffness, has been proposed as a mechanism driving directed migration. Despite lack evidence for its existence in vivo, durotaxis become an active field research, focusing on respond to stimuli from environment. In this review, we describe technical and conceptual advances study vitro, discuss what extent sugges...