Background: The skin serves as the first line of defense for human body. Direct sunlight contains damaging radiations that can speed up ageing process skin, resulting in wrinkles, leathery dark patches, and solar elastosis. Objectives: To evaluate effect multiple irradiation related factors at protein level dermal fibroblast (HDF). overall individual irradiations such Infrared A (IRA), blue lig...

The purpose of the study was to compare the binding energy of pharmacophores of different classes targeting to kappa opioid receptor (KOR) with ketazocine and pentazocine which are having good activity on the KOR. The 3D structure of KOR receptor was built by Homology modeling; pharmacophores were characterized by using Ligand scout. Docking studies for the KOR agonists were performed in Autodo...

Leishmaniasis is a protozoal disease which afflicts the world’s poorest population with endemic distribution in 88 countries around the world and has been considered as a major tropical disease by the world health organization (WHO). P-glycoprotein (P-gp) is an ATP-dependent pump that exports a wide range of drugs from the cell, decreasing their intracellular concentration and preventing their ...

Methods Fresh ink glands from Loligo duvauceli were dissected and the ink was subjected to crude solvent extraction. Chromatographic profiles were assessed by TLC and HPTLC. Fractionation of the bio active compounds was done by Silica gel column chromatography and the active fraction was subjected to GC-MS analysis. In vitro analysis of the anti-HBV like activity was assessed by pre incubating ...

Cancer is one of the major life threatening diseases worldwide. Many studies are in progress to inhibit the rate of distribution of the proteins involved in cancer. The Aloe Vera compounds were checked against the molecular targets of cancer by molecular docking studies. The compounds n-Hexadecanoic acid and tertadecanoic acid were found to interact more towards the target protein showing highe...

Ayurvedha and Herbal medicine are two important forms of alternative medicine that are widely available. Medicinal plants have disease curing properties and this is due to the compounds presents in the extracts. This work is mainly concerned with the identification of the therapeutic properties of Indian medicinal plant extracts. So we identified the compounds of different medicinal plants like...

Periodontal diseases are highly prevalent oral conditions associated with severe complications in the cavity. These inflammatory caused by microbiome and influenced several factors, such as aging, tobacco usage, systemic illness inadequate hygiene. Plant-derived phytochemicals extensively utilized managing various periodontal due to presence of antioxidant, anti-inflammatory antibacterial activ...

Objectives: To analyse CPEB3 using bioinformatic tools in several types of cancer, various HNSCC cell lines based on cancer stages, tumour grades and the gene interaction, protein regulating pathway, microRNA survival analysis. Methods: Bioinformatics used were UALCAN, TCGA, NCBI, GEPIA, Oncomine, cBioPortal, Human Protein Atlas, STRING, Metascape, miRNA Target Prediction Database. Findings: ex...