in this study, the effects of late gestational undernutrition (lgu) on plasma concentration of insulin-like growth factor 1 (igf-i), leptin, insulin and glucose in subsequent sucking lambs was investigated. ten twin-bearing ewes were fed either restrictedly (restricted) or adequately (control) during the last six weeks of gestation and were fed ad libitum after parturition. blood samples were t...

BACKGROUND Insulin-like growth factor-1 (IGF-1) promotes the survival of cardiomyocytes by activating type 1 IGF receptor (IGF-1R). Within the myocardium, IGF-1 action is modulated by IGF binding protein-3 (IGFBP-3), which sequesters IGF-1 away from IGF-1R. Since cardiomyocyte apoptosis is implicated in anthracycline cardiotoxicity, we investigated the effects of the anthracycline, doxorubicin,...