We report the experimental realization of plasmonic heterodimers, pairs of directly adjacent, interacting metallic nanoparticles. A novel fabrication and positioning approach is utilized for the stepwise assembly of upright nanoparticle pairs, where the first nanoparticle is almost entirely embedded in an elastomeric dielectric medium prior to attachment of the second nanoparticle. The plasmon ...

context since 2006 a relevant number of therapeutical algorithms for the management of type 2 diabetes have been proposed, generating a lively debate in the scientific community, particularly on the ideal timing for introduction of insulin therapy and on which drug should be preferred as add-on therapy in patients failing to metformin. at the moment, there is no real consensus. the aim of the p...

The size of gold nanoparticle aggregates was controlled by manipulating the interparticle interaction. To manipulate the interparticle interaction of gold nanoparticles prepared by citrate reduction, we applied the substitutive adsorption of benzyl mercaptan on the particle surface in the absence of the cross-linking effect. Various experimental techniques such as UV-vis absorption spectroscopy...

Nanoparticles used in biological applications encounter a complex mixture of extracellular proteins. Adsorption of these proteins on the nanoparticle surface results in the formation of a "protein corona," which can dominate the interaction of the nanoparticle with the cellular environment. The goal of this research was to determine how nanoparticle composition and surface modification affect t...

Metal nanoparticles have been investigated as an efficient method to enhance the light absorption in thin film solar cell due to the surface plasmonic scattering. In this paper, we studied the light trapping by modifying the common silicon-nanoparticle-dielectric-back reflector structure. We reported the short circuit current (Jsc) enhancement of a two-layer nanoparticle structure, coated with ...

Sensitive DNA detection is extremely important in clinical diagnostics, gene therapy, and a variety of biomedical studies. We have developed a novel DNA bioanalysis method with a 0.8 fM (0.8 x 10-15 M) detection limit using a bioconjugated fluorescent nanoparticle-based sandwich assay. An organic dye silica nanoparticle is synthesized using a modified reverse microemulsion. The nanoparticles ar...

The aims of this study were to improve in vitro dissolution property of poorly water-soluble everolimus (EVR) for enhanced bioavailability without using organic solvents and characterize the effects of microfluidization and freeze-drying on physicochemical properties of EVR nanosuspension and nanoparticle, respectively. EVR nanosuspension was prepared using microfluidization with various types ...

molecular dynamics simulation has been performed to analyze the effect of the presence of gold nanoparticle on dynamics of kob-anderson binary lennard-jones (blj) mixture upon supercooling within the framework of the mode coupling theory of the dynamic glass transition. the presence of gold nanoparticle has a direct effect on the liquid structure and causes the peaks of the radial distribution ...

AIM To investigated the dose enhancement due to the incorporation of nanoparticles in skin therapy using the kilovoltage (kV) photon and megavoltage (MV) electron beams. Monte Carlo simulations were used to predict the dose enhancement when different types and concentrations of nanoparticles were added to skin target layers of varying thickness. METHODS Clinical kV photon beams (105 and 220 k...

Self-assembled monolayer (SAM) formation of alkanethiols on nanoparticle surfaces is an extensively studied surface reaction. But the nanoscale aspects of the rich microscopic kinetics of this reaction may remain hidden due to ensemble-averaging in colloidal samples, which is why we investigated in real-time how alkanethiol SAMs form on a single Ag nanoparticle. From single-nanoparticle traject...