The responsibility of diabetes management and insulin therapy has definitively moved to primary care physicians. Within the primary care setting, there is a growing need for clear, evidence-based guidelines related to the management of insulin therapy. Straightforward algorithms regarding insulin initiation, titration, and follow-up management can help physicians effectively treat patients with...

AIMS/INTRODUCTION We investigated the association between four insulin regimens, and increase in glycated hemoglobin (HbA1c) and insulin dose in a real-life clinical setting because there are no data about them among insulin regimens. MATERIALS AND METHODS Participants included 757 patients with type 2 diabetes having been treated with insulin therapy for more than 1 year. The four insulin re...

Insulin potentiation therapy (IPT) is an unproven adjunct to cancer chemotherapy that uses insulin followed by sub-therapeutic doses of chemotherapy or other medications well below their proven efficacy. Theoretically, IPT boosts the pharmacologic efficacy of medications by increasing uptake into the cells of the body. During IPT enough insulin is given to induce hypoglycemic shock (perspiratio...

IN BRIEF Six million people with diabetes use insulin either alone or in combination with an oral medication. Many barriers exist that lead to poor adherence with insulin. However, there is an underwhelming amount of data on interventions to address these barriers and improve insulin adherence. Until pharmacological advancements create easier, more acceptable insulin regimens, it is imperative ...

BACKGROUND Some patients with type 2 diabetes mellitus (T2DM) on insulin have poor glycemic control and require add-on therapy to reach target glucose values. Increased insulin doses or the addition of an oral antidiabetic drug (OAD) may improve glycemic control, but many patients fail to achieve target values. The aim of this study was to compare the treatment efficacy and safety of three diff...

The objective of this study was to compare glycemic control and insulin dosage in children with type 1 diabetes treated by a modified intensified insulin therapy MII using insulin pens (and premixed and regular insulin) with those on conventional insulin therapy. This was a longitudinal, randomized controlled trial for 6 months or more. From a cohort of 125 children with previously diagnosed ty...

UNLABELLED Aims/Introduction:  Insulin therapy is often required to achieve good glycemic control in patients with type 2 diabetes mellitus. However, some providers, particularly general practitioners (GPs), are reluctant to prescribe insulin to their patients. The aim of the present study was to clarify any differences in, as well as any problems associated with, insulin therapy in patients wi...

OBJECTIVE The aim of the study was to define parameters that influence the initial insulin dosage in young subjects with type 1 diabetes regarding the amount of daily insulin, the ratios of basal and prandial insulin, and the insulin/carbohydrate ratios. STUDY DESIGN We used a computer-based registry (with prospectively collected data) in Germany and Austria, a software for the management and...

Lowering the glucose level in diabetic patients reduces the risk of many consequences which are usually reported in these patients. Non-insulin dependent (type II) diabetes which cannot be controlled with sulfonylureas alone can be controlled with a combination of sulfonylurea and insulin. In an open randomized trial 58 patients were divided into three groups. The fIrst group received only ...

T congenital malformation remains the leading cause of mortality and serious morbidity in infants of mother with type 1 or type 2 diabetes, inspite of advancement in understanding pregnancy metabolism and treatment. Studies have established association between elevated maternal glucose during embryogenesis and high rates of spontaneous abortions and major malformations in newborn. Clinical tria...